1SGO
NMR Structure of the human C14orf129 gene product, HSPC210. Northeast Structural Genomics target HR969.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004860 | molecular_function | protein kinase inhibitor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006469 | biological_process | negative regulation of protein kinase activity |
| A | 0008013 | molecular_function | beta-catenin binding |
| A | 0008631 | biological_process | intrinsic apoptotic signaling pathway in response to oxidative stress |
| A | 0019207 | molecular_function | kinase regulator activity |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0030111 | biological_process | regulation of Wnt signaling pathway |
| A | 0034237 | molecular_function | protein kinase A regulatory subunit binding |
| A | 0051018 | molecular_function | protein kinase A binding |
| A | 0060828 | biological_process | regulation of canonical Wnt signaling pathway |
| A | 0090263 | biological_process | positive regulation of canonical Wnt signaling pathway |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 21 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Region: {"description":"Required for PRKAR2A interaction; contributes to a protective effect against H(2)O(2)-induced apoptosis","evidences":[{"source":"PubMed","id":"25920809","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Region: {"description":"Interaction with GSK3B and acts as a GSK3B inhibitor","evidences":[{"source":"PubMed","id":"16981698","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Required for GSK3B interaction; contributes to a protective effect against H(2)O(2)-induced apoptosis","evidences":[{"source":"PubMed","id":"16981698","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25920809","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27484798","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
