1SGO

NMR Structure of the human C14orf129 gene product, HSPC210. Northeast Structural Genomics target HR969.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004860	molecular_function	protein kinase inhibitor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006469	biological_process	negative regulation of protein kinase activity
A	0008013	molecular_function	beta-catenin binding
A	0008631	biological_process	intrinsic apoptotic signaling pathway in response to oxidative stress
A	0019207	molecular_function	kinase regulator activity
A	0019901	molecular_function	protein kinase binding
A	0030111	biological_process	regulation of Wnt signaling pathway
A	0034237	molecular_function	protein kinase A regulatory subunit binding
A	0051018	molecular_function	protein kinase A binding
A	0060828	biological_process	regulation of canonical Wnt signaling pathway
A	0090263	biological_process	positive regulation of canonical Wnt signaling pathway

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Required for GSK3B interaction; contributes to a protective effect against H(2)O(2)-induced apoptosis => ECO:0000269|PubMed:16981698, ECO:0000269|PubMed:25920809, ECO:0000269|PubMed:27484798

Chain	Residue	Details
A	LEU130

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