1SGN

ASN 18 VARIANT OF TURKEY OVOMUCOID INHIBITOR THIRD DOMAIN COMPLEXED WITH STREPTOMYCES GRISEUS PROTEINASE B

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004252	molecular_function	serine-type endopeptidase activity
E	0006508	biological_process	proteolysis
I	0004867	molecular_function	serine-type endopeptidase inhibitor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 E 500

Chain	Residue
I	LYS55
E	TYR32
E	ARG41
E	HOH595
I	TYR20

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site_id	ACT
Number of Residues	3
Details	ACTIVE SITE

Chain	Residue
E	HIS57
E	ASP102
E	SER195

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site_id	REA
Number of Residues	2
Details	REACTIVE SITE

Chain	Residue
I	ASN18
I	GLU19

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Functional Information from PROSITE/UniProt

site_id	PS00282
Number of Residues	23
Details	KAZAL_1 Kazal serine protease inhibitors family signature. CtneyRplCgSdnktYgnkCnf.C

Chain	Residue	Details
I	CYS16-CYS38

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site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAGHC

Chain	Residue	Details
E	LEU53-CYS58

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. CAepGDSGGPLY

Chain	Residue	Details
E	CYS191-TYR200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Reactive bond 3 for chymotrypsin, elastase, proteases A and B, and subtilisin

Chain	Residue	Details
I	ASN18
E	ASP102
E	SER195

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine

Chain	Residue	Details
I	ASN45

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 608

Chain	Residue	Details
E	HIS57	proton acceptor, proton donor
E	ASP102	electrostatic stabiliser
E	GLY193	electrostatic stabiliser
E	SER195	nucleofuge, nucleophile, proton acceptor, proton donor
E	SER214	electrostatic stabiliser

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