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1SFI

High resolution structure of a potent, cyclic protease inhibitor from sunflower seeds

Functional Information from GO Data
ChainGOidnamespacecontents
A0004175molecular_functionendopeptidase activity
A0004252molecular_functionserine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006508biological_processproteolysis
A0007586biological_processdigestion
A0008233molecular_functionpeptidase activity
A0008236molecular_functionserine-type peptidase activity
A0016787molecular_functionhydrolase activity
A0046872molecular_functionmetal ion binding
A0097180cellular_componentserine protease inhibitor complex
A0097655molecular_functionserpin family protein binding
I0004867molecular_functionserine-type endopeptidase inhibitor activity
I0005576cellular_componentextracellular region
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A 1
ChainResidue
AARG66
ASER166
ASER167
ASER170
AHOH427
AHOH484
AHOH516
AHOH596

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 2
ChainResidue
ASER130
ATHR134
ASER202
AHOH409
AHOH446
AHOH510
AALA129

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 A 3
ChainResidue
ALYS169
APRO173
AGLY174
AHOH421
AHOH457
AHOH599

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA A 246
ChainResidue
AGLU70
AASN72
AVAL75
AGLU80

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC
ChainResidueDetails
AVAL53-CYS58

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV
ChainResidueDetails
AASP189-VAL200

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Charge relay system
ChainResidueDetails
ALYS60
ALEU105
APRO198

site_idSWS_FT_FI2
Number of Residues7
DetailsBINDING:
ChainResidueDetails
AILE73
AVAL75
AGLY78
AILE83
AGLN192
ASER195
APRO198

218853

PDB entries from 2024-04-24

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