1SFC
NEURONAL SYNAPTIC FUSION COMPLEX
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0016020 | cellular_component | membrane |
A | 0016192 | biological_process | vesicle-mediated transport |
B | 0005484 | molecular_function | SNAP receptor activity |
B | 0006886 | biological_process | intracellular protein transport |
B | 0016020 | cellular_component | membrane |
B | 0016192 | biological_process | vesicle-mediated transport |
C | 0000149 | molecular_function | SNARE binding |
C | 0005249 | molecular_function | voltage-gated potassium channel activity |
C | 0017075 | molecular_function | syntaxin-1 binding |
E | 0016020 | cellular_component | membrane |
E | 0016192 | biological_process | vesicle-mediated transport |
F | 0005484 | molecular_function | SNAP receptor activity |
F | 0006886 | biological_process | intracellular protein transport |
F | 0016020 | cellular_component | membrane |
F | 0016192 | biological_process | vesicle-mediated transport |
G | 0000149 | molecular_function | SNARE binding |
G | 0005249 | molecular_function | voltage-gated potassium channel activity |
G | 0017075 | molecular_function | syntaxin-1 binding |
I | 0016020 | cellular_component | membrane |
I | 0016192 | biological_process | vesicle-mediated transport |
J | 0005484 | molecular_function | SNAP receptor activity |
J | 0006886 | biological_process | intracellular protein transport |
J | 0016020 | cellular_component | membrane |
J | 0016192 | biological_process | vesicle-mediated transport |
K | 0000149 | molecular_function | SNARE binding |
K | 0005249 | molecular_function | voltage-gated potassium channel activity |
K | 0017075 | molecular_function | syntaxin-1 binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE SR D 288 |
Chain | Residue |
D | HOH516 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SR A 289 |
Chain | Residue |
A | ASP68 |
A | HOH513 |
I | SER75 |
I | GLU78 |
I | THR79 |
I | HOH506 |
I | HOH510 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SR A 290 |
Chain | Residue |
A | GLU78 |
A | THR79 |
A | HOH507 |
I | ASP68 |
I | MPD930 |
A | SER75 |
site_id | AC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SR F 291 |
Chain | Residue |
F | ASP242 |
F | GLU245 |
F | HOH504 |
F | HOH511 |
J | ASP242 |
J | GLU245 |
J | HOH508 |
site_id | AC5 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE SR J 292 |
Chain | Residue |
J | ASP218 |
site_id | AC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SR K 293 |
Chain | Residue |
G | ASP41 |
K | GLU37 |
site_id | AC7 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE SR B 294 |
Chain | Residue |
B | ASP218 |
site_id | AC8 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SR C 295 |
Chain | Residue |
C | GLU55 |
C | HOH519 |
site_id | AC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SR C 296 |
Chain | Residue |
C | ASP51 |
C | GLU55 |
C | HOH519 |
site_id | BC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SR F 297 |
Chain | Residue |
F | ASP214 |
F | ASP218 |
F | HOH501 |
site_id | BC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SR G 298 |
Chain | Residue |
G | ASP51 |
G | GLU55 |
G | SR299 |
G | SR300 |
K | ASP51 |
K | GLU55 |
site_id | BC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SR G 299 |
Chain | Residue |
G | ASP51 |
G | SR298 |
K | GLU52 |
K | GLU55 |
site_id | BC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SR G 300 |
Chain | Residue |
G | GLU55 |
G | SR298 |
K | ASP51 |
K | GLU55 |
K | MPD929 |
site_id | BC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MPD F 926 |
Chain | Residue |
B | ASP231 |
C | GLU52 |
C | GLN53 |
E | GLN71 |
F | TYR235 |
F | ASN236 |
site_id | BC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MPD A 927 |
Chain | Residue |
A | ARG86 |
A | TRP89 |
I | ASP57 |
J | SER225 |
J | MET229 |
site_id | BC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE MPD A 928 |
Chain | Residue |
A | ASP65 |
A | ASP68 |
site_id | BC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MPD K 929 |
Chain | Residue |
G | SR300 |
K | LYS76 |
K | ASP80 |
L | GLU170 |
site_id | BC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MPD I 930 |
Chain | Residue |
A | GLN76 |
A | THR79 |
A | SR290 |
I | ASP68 |
I | ALA69 |
site_id | CC1 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE MPD K 931 |
Chain | Residue |
K | GLN15 |
site_id | CC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MPD G 932 |
Chain | Residue |
F | GLU245 |
G | HIS66 |
G | GLN69 |
G | ASP70 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 180 |
Details | Domain: {"description":"v-SNARE coiled-coil homology","evidences":[{"source":"PROSITE-ProRule","id":"PRU00290","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | Site: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type F (BoNT/F, botF)","evidences":[{"source":"PubMed","id":"8505288","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 3 |
Details | Site: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type D (BoNT/D, botD)","evidences":[{"source":"PubMed","id":"8175689","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | Site: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type X (BoNT/X)","evidences":[{"source":"PubMed","id":"28770820","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI5 |
Number of Residues | 3 |
Details | Site: {"description":"(Microbial infection) Cleavage; by C.tetani tetanus toxin (tetX)","evidences":[{"source":"PubMed","id":"1331807","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI6 |
Number of Residues | 3 |
Details | Site: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type G (BoNT/G, botG)","evidences":[{"source":"PubMed","id":"7910017","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI7 |
Number of Residues | 186 |
Details | Domain: {"description":"t-SNARE coiled-coil homology","evidences":[{"source":"PROSITE-ProRule","id":"PRU00202","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI8 |
Number of Residues | 3 |
Details | Site: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type C (BoNT/C)","evidences":[{"source":"PubMed","id":"7737992","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | Modified residue: {"description":"Phosphoserine; by DAPK1","evidences":[{"source":"PubMed","id":"12730201","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI10 |
Number of Residues | 12 |
Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"UniProtKB","id":"Q16623","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI11 |
Number of Residues | 186 |
Details | Domain: {"description":"t-SNARE coiled-coil homology 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00202","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI12 |
Number of Residues | 186 |
Details | Domain: {"description":"t-SNARE coiled-coil homology 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00202","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI13 |
Number of Residues | 3 |
Details | Site: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type E (BoNT/E)","evidences":[{"source":"PubMed","id":"8243676","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8294407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8103915","evidenceCode":"ECO:0000305"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI14 |
Number of Residues | 3 |
Details | Site: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type A (BoNT/A, botA)","evidences":[{"source":"PubMed","id":"8243676","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8294407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8103915","evidenceCode":"ECO:0000305"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI15 |
Number of Residues | 3 |
Details | Modified residue: {"description":"Phosphothreonine; by PKC and PKA","evidences":[{"source":"PubMed","id":"12459461","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI16 |
Number of Residues | 3 |
Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P60879","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI17 |
Number of Residues | 3 |
Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"12459461","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |