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1SFC

NEURONAL SYNAPTIC FUSION COMPLEX

Functional Information from GO Data
ChainGOidnamespacecontents
A0016020cellular_componentmembrane
A0016192biological_processvesicle-mediated transport
B0005484molecular_functionSNAP receptor activity
B0006886biological_processintracellular protein transport
B0016020cellular_componentmembrane
B0016192biological_processvesicle-mediated transport
C0000149molecular_functionSNARE binding
C0005249molecular_functionvoltage-gated potassium channel activity
C0017075molecular_functionsyntaxin-1 binding
E0016020cellular_componentmembrane
E0016192biological_processvesicle-mediated transport
F0005484molecular_functionSNAP receptor activity
F0006886biological_processintracellular protein transport
F0016020cellular_componentmembrane
F0016192biological_processvesicle-mediated transport
G0000149molecular_functionSNARE binding
G0005249molecular_functionvoltage-gated potassium channel activity
G0017075molecular_functionsyntaxin-1 binding
I0016020cellular_componentmembrane
I0016192biological_processvesicle-mediated transport
J0005484molecular_functionSNAP receptor activity
J0006886biological_processintracellular protein transport
J0016020cellular_componentmembrane
J0016192biological_processvesicle-mediated transport
K0000149molecular_functionSNARE binding
K0005249molecular_functionvoltage-gated potassium channel activity
K0017075molecular_functionsyntaxin-1 binding
Functional Information from PDB Data
site_idAC1
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SR D 288
ChainResidue
DHOH516

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SR A 289
ChainResidue
AASP68
AHOH513
ISER75
IGLU78
ITHR79
IHOH506
IHOH510

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SR A 290
ChainResidue
AGLU78
ATHR79
AHOH507
IASP68
IMPD930
ASER75

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SR F 291
ChainResidue
FASP242
FGLU245
FHOH504
FHOH511
JASP242
JGLU245
JHOH508

site_idAC5
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SR J 292
ChainResidue
JASP218

site_idAC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SR K 293
ChainResidue
GASP41
KGLU37

site_idAC7
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SR B 294
ChainResidue
BASP218

site_idAC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SR C 295
ChainResidue
CGLU55
CHOH519

site_idAC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SR C 296
ChainResidue
CASP51
CGLU55
CHOH519

site_idBC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SR F 297
ChainResidue
FASP214
FASP218
FHOH501

site_idBC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SR G 298
ChainResidue
GASP51
GGLU55
GSR299
GSR300
KASP51
KGLU55

site_idBC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SR G 299
ChainResidue
GASP51
GSR298
KGLU52
KGLU55

site_idBC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SR G 300
ChainResidue
GGLU55
GSR298
KASP51
KGLU55
KMPD929

site_idBC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MPD F 926
ChainResidue
BASP231
CGLU52
CGLN53
EGLN71
FTYR235
FASN236

site_idBC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MPD A 927
ChainResidue
AARG86
ATRP89
IASP57
JSER225
JMET229

site_idBC7
Number of Residues2
DetailsBINDING SITE FOR RESIDUE MPD A 928
ChainResidue
AASP65
AASP68

site_idBC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MPD K 929
ChainResidue
GSR300
KLYS76
KASP80
LGLU170

site_idBC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MPD I 930
ChainResidue
AGLN76
ATHR79
ASR290
IASP68
IALA69

site_idCC1
Number of Residues1
DetailsBINDING SITE FOR RESIDUE MPD K 931
ChainResidue
KGLN15

site_idCC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MPD G 932
ChainResidue
FGLU245
GHIS66
GGLN69
GASP70

Functional Information from PROSITE/UniProt
site_idPS00417
Number of Residues20
DetailsSYNAPTOBREVIN Synaptobrevin signature. NVDKVlERdqKLSeLdDRAD
ChainResidueDetails
AASN49-ASP68

site_idPS00914
Number of Residues40
DetailsSYNTAXIN Syntaxin / epimorphin family signature. RhseIikLEnsIrELhdMFmdMamlVesQGemIDrIEyn.V
ChainResidueDetails
BARG198-VAL237

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues180
DetailsDomain: {"description":"v-SNARE coiled-coil homology","evidences":[{"source":"PROSITE-ProRule","id":"PRU00290","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues3
DetailsSite: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type F (BoNT/F, botF)","evidences":[{"source":"PubMed","id":"8505288","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues3
DetailsSite: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type D (BoNT/D, botD)","evidences":[{"source":"PubMed","id":"8175689","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues3
DetailsSite: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type X (BoNT/X)","evidences":[{"source":"PubMed","id":"28770820","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues3
DetailsSite: {"description":"(Microbial infection) Cleavage; by C.tetani tetanus toxin (tetX)","evidences":[{"source":"PubMed","id":"1331807","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues3
DetailsSite: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type G (BoNT/G, botG)","evidences":[{"source":"PubMed","id":"7910017","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues186
DetailsDomain: {"description":"t-SNARE coiled-coil homology","evidences":[{"source":"PROSITE-ProRule","id":"PRU00202","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues3
DetailsSite: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type C (BoNT/C)","evidences":[{"source":"PubMed","id":"7737992","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by DAPK1","evidences":[{"source":"PubMed","id":"12730201","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues12
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"UniProtKB","id":"Q16623","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues186
DetailsDomain: {"description":"t-SNARE coiled-coil homology 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00202","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues186
DetailsDomain: {"description":"t-SNARE coiled-coil homology 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00202","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues3
DetailsSite: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type E (BoNT/E)","evidences":[{"source":"PubMed","id":"8243676","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8294407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8103915","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues3
DetailsSite: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type A (BoNT/A, botA)","evidences":[{"source":"PubMed","id":"8243676","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8294407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8103915","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues3
DetailsModified residue: {"description":"Phosphothreonine; by PKC and PKA","evidences":[{"source":"PubMed","id":"12459461","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P60879","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI17
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"12459461","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

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