1SD9
ARSENATE REDUCTASE C12S MUTANT +0.4M ARSENATE FROM E. COLI
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 201 |
| Chain | Residue |
| A | SER12 |
| A | HOH1090 |
| A | GLY13 |
| A | THR14 |
| A | ARG60 |
| A | ASN62 |
| A | ARG94 |
| A | ARG107 |
| A | HOH1008 |
| A | HOH1076 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 202 |
| Chain | Residue |
| A | ARG107 |
| A | HOH1062 |
| A | HOH1101 |
| A | HOH1223 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE SO4 A 203 |
| Chain | Residue |
| A | THR14 |
| A | ASN17 |
| A | PRO108 |
| A | SER109 |
| A | GLU110 |
| A | LYS126 |
| A | HOH1008 |
| A | HOH1023 |
| A | HOH1087 |
| A | HOH1093 |
| A | HOH1193 |
| A | HOH1213 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CS A 401 |
| Chain | Residue |
| A | LEU113 |
| A | LEU113 |
| A | ASP114 |
| A | ASP114 |
| A | LEU116 |
| A | LEU116 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CS A 402 |
| Chain | Residue |
| A | PRO38 |
| A | GLU43 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile; cysteine thioarsenate intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU01282","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11709171","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15295115","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7577935","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for activity. Lowers pKa of the active site Cys","evidences":[{"source":"PubMed","id":"8969183","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Site: {"description":"Important for activity. Involved in arsenate binding and transition-state stabilization","evidences":[{"source":"PubMed","id":"11709171","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14592722","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15295115","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
