1S8E

Crystal structure of Mre11-3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000729	biological_process	DNA double-strand break processing
A	0016787	molecular_function	hydrolase activity
B	0000729	biological_process	DNA double-strand break processing
B	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN A 401

Chain	Residue
A	ASP49
A	ASN84
A	HIS173
A	HIS206
A	MN402
A	HOH602
A	HOH630

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN A 402

Chain	Residue
A	ASP49
A	HIS208
A	MN401
A	HOH602
A	HOH630
A	ASP8
A	HIS10

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN B 403

Chain	Residue
B	ASP8
B	HIS10
B	ASP49
B	HIS208
B	MN404
B	HOH605

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN B 404

Chain	Residue
B	ASP49
B	ASN84
B	HIS173
B	HIS206
B	MN403
B	HOH601
B	HOH605

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_02044","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11371344","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15047855","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11371344","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15047855","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18854158","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23080121","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1II7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1S8E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DSD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HD0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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