Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006508 | biological_process | proteolysis |
| A | 0007586 | biological_process | digestion |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 1 |
| Chain | Residue |
| A | GLU70 |
| A | ASN72 |
| A | VAL75 |
| A | GLU77 |
| A | GLU80 |
| A | HOH293 |
| A | HOH468 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2 |
| Chain | Residue |
| A | HOH326 |
| A | HOH412 |
| A | HOH478 |
| A | HOH490 |
| A | ASN48 |
| A | ARG66 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 3 |
| Chain | Residue |
| A | ASN95 |
| A | ASN97 |
| A | THR98 |
| A | HOH413 |
| A | HOH483 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 4 |
| Chain | Residue |
| A | EDO5 |
| A | ASP189 |
| A | SER190 |
| A | GLY226 |
| A | HOH300 |
| A | HOH454 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE EDO A 5 |
| Chain | Residue |
| A | NA4 |
| A | SBE12 |
| A | SER190 |
| A | CYS191 |
| A | GLN192 |
| A | SER195 |
| A | VAL213 |
| A | TRP215 |
| A | GLY216 |
| A | HOH261 |
| A | HOH300 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 6 |
| Chain | Residue |
| A | THR21 |
| A | HOH299 |
| A | HOH486 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 7 |
| Chain | Residue |
| A | LYS87 |
| A | LYS107 |
| A | GLU135 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 8 |
| Chain | Residue |
| A | GLY96 |
| A | ASN97 |
| A | LEU99 |
| A | SER127 |
| A | GLN204 |
| A | GLN210 |
| A | HOH385 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO A 9 |
| Chain | Residue |
| A | SER37 |
| A | LYS60 |
| A | SER164 |
| A | ASP165 |
| A | SER166 |
| A | HOH392 |
| A | HOH395 |
| A | HOH484 |
| A | HOH485 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 10 |
| Chain | Residue |
| A | ILE47 |
| A | ASN48 |
| A | TYR217 |
| A | GLN239 |
| A | ILE242 |
| A | HOH479 |
| site_id | BC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO A 11 |
| Chain | Residue |
| A | HIS91 |
| A | ASN101 |
| A | GLY148 |
| A | SER149 |
| A | ASN179 |
| A | ASN233 |
| A | HOH306 |
| A | HOH316 |
| A | HOH343 |
| site_id | BC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SBE A 12 |
| Chain | Residue |
| A | EDO5 |
| A | PHE41 |
| A | HIS57 |
| A | GLN192 |
| A | GLY193 |
| A | SER195 |
| A | HOH282 |
| A | HOH376 |
| A | HOH403 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC |
| Chain | Residue | Details |
| A | VAL53-CYS58 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV |
| Chain | Residue | Details |
| A | ASP189-VAL200 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| A | HIS57 | |
| A | ASP102 | |
| A | SER195 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLU70 | |
| A | ASN72 | |
| A | VAL75 | |
| A | GLU80 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Required for specificity => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP189 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | HIS57 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER195 | |
| A | GLY196 | |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER195 | |
| A | GLY193 | |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | HIS57 | |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | HIS57 | |
| A | GLY196 | |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | GLY193 | |
| A | HIS57 | |
