1S7U

Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 index peptide and three of its escape variants

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001913	biological_process	T cell mediated cytotoxicity
A	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
A	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
A	0002485	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006955	biological_process	immune response
A	0009897	cellular_component	external side of plasma membrane
A	0010977	biological_process	negative regulation of neuron projection development
A	0016020	cellular_component	membrane
A	0019882	biological_process	antigen processing and presentation
A	0030670	cellular_component	phagocytic vesicle membrane
A	0042612	cellular_component	MHC class I protein complex
A	0098553	cellular_component	lumenal side of endoplasmic reticulum membrane
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0006968	biological_process	cellular defense response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0010977	biological_process	negative regulation of neuron projection development
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0030670	cellular_component	phagocytic vesicle membrane
B	0033077	biological_process	T cell differentiation in thymus
B	0034756	biological_process	regulation of iron ion transport
B	0042026	biological_process	protein refolding
B	0042612	cellular_component	MHC class I protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0051289	biological_process	protein homotetramerization
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
D	0001913	biological_process	T cell mediated cytotoxicity
D	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
D	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
D	0002485	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0006955	biological_process	immune response
D	0009897	cellular_component	external side of plasma membrane
D	0010977	biological_process	negative regulation of neuron projection development
D	0016020	cellular_component	membrane
D	0019882	biological_process	antigen processing and presentation
D	0030670	cellular_component	phagocytic vesicle membrane
D	0042612	cellular_component	MHC class I protein complex
D	0098553	cellular_component	lumenal side of endoplasmic reticulum membrane
E	0001913	biological_process	T cell mediated cytotoxicity
E	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
E	0002237	biological_process	response to molecule of bacterial origin
E	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
E	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
E	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
E	0002726	biological_process	positive regulation of T cell cytokine production
E	0005198	molecular_function	structural molecule activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005794	cellular_component	Golgi apparatus
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006826	biological_process	iron ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0006955	biological_process	immune response
E	0006968	biological_process	cellular defense response
E	0007608	biological_process	sensory perception of smell
E	0007611	biological_process	learning or memory
E	0009897	cellular_component	external side of plasma membrane
E	0010977	biological_process	negative regulation of neuron projection development
E	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
E	0030670	cellular_component	phagocytic vesicle membrane
E	0033077	biological_process	T cell differentiation in thymus
E	0034756	biological_process	regulation of iron ion transport
E	0042026	biological_process	protein refolding
E	0042612	cellular_component	MHC class I protein complex
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0042824	cellular_component	MHC class I peptide loading complex
E	0045646	biological_process	regulation of erythrocyte differentiation
E	0048260	biological_process	positive regulation of receptor-mediated endocytosis
E	0050680	biological_process	negative regulation of epithelial cell proliferation
E	0050768	biological_process	negative regulation of neurogenesis
E	0051289	biological_process	protein homotetramerization
E	0060586	biological_process	multicellular organismal-level iron ion homeostasis
E	0071281	biological_process	cellular response to iron ion
E	0071283	biological_process	cellular response to iron(III) ion
E	0071316	biological_process	cellular response to nicotine
E	1990000	biological_process	amyloid fibril formation
E	1990712	cellular_component	HFE-transferrin receptor complex
E	2000774	biological_process	positive regulation of cellular senescence
E	2000978	biological_process	negative regulation of forebrain neuron differentiation
G	0001913	biological_process	T cell mediated cytotoxicity
G	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
G	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
G	0002485	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
G	0005515	molecular_function	protein binding
G	0005886	cellular_component	plasma membrane
G	0006955	biological_process	immune response
G	0009897	cellular_component	external side of plasma membrane
G	0010977	biological_process	negative regulation of neuron projection development
G	0016020	cellular_component	membrane
G	0019882	biological_process	antigen processing and presentation
G	0030670	cellular_component	phagocytic vesicle membrane
G	0042612	cellular_component	MHC class I protein complex
G	0098553	cellular_component	lumenal side of endoplasmic reticulum membrane
H	0001913	biological_process	T cell mediated cytotoxicity
H	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
H	0002237	biological_process	response to molecule of bacterial origin
H	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
H	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
H	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
H	0002726	biological_process	positive regulation of T cell cytokine production
H	0005198	molecular_function	structural molecule activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005794	cellular_component	Golgi apparatus
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0006955	biological_process	immune response
H	0006968	biological_process	cellular defense response
H	0007608	biological_process	sensory perception of smell
H	0007611	biological_process	learning or memory
H	0009897	cellular_component	external side of plasma membrane
H	0010977	biological_process	negative regulation of neuron projection development
H	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
H	0030670	cellular_component	phagocytic vesicle membrane
H	0033077	biological_process	T cell differentiation in thymus
H	0034756	biological_process	regulation of iron ion transport
H	0042026	biological_process	protein refolding
H	0042612	cellular_component	MHC class I protein complex
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0042824	cellular_component	MHC class I peptide loading complex
H	0045646	biological_process	regulation of erythrocyte differentiation
H	0048260	biological_process	positive regulation of receptor-mediated endocytosis
H	0050680	biological_process	negative regulation of epithelial cell proliferation
H	0050768	biological_process	negative regulation of neurogenesis
H	0051289	biological_process	protein homotetramerization
H	0060586	biological_process	multicellular organismal-level iron ion homeostasis
H	0071281	biological_process	cellular response to iron ion
H	0071283	biological_process	cellular response to iron(III) ion
H	0071316	biological_process	cellular response to nicotine
H	1990000	biological_process	amyloid fibril formation
H	1990712	cellular_component	HFE-transferrin receptor complex
H	2000774	biological_process	positive regulation of cellular senescence
H	2000978	biological_process	negative regulation of forebrain neuron differentiation
J	0001913	biological_process	T cell mediated cytotoxicity
J	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
J	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
J	0002485	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
J	0005515	molecular_function	protein binding
J	0005886	cellular_component	plasma membrane
J	0006955	biological_process	immune response
J	0009897	cellular_component	external side of plasma membrane
J	0010977	biological_process	negative regulation of neuron projection development
J	0016020	cellular_component	membrane
J	0019882	biological_process	antigen processing and presentation
J	0030670	cellular_component	phagocytic vesicle membrane
J	0042612	cellular_component	MHC class I protein complex
J	0098553	cellular_component	lumenal side of endoplasmic reticulum membrane
K	0001913	biological_process	T cell mediated cytotoxicity
K	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
K	0002237	biological_process	response to molecule of bacterial origin
K	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
K	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
K	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
K	0002726	biological_process	positive regulation of T cell cytokine production
K	0005198	molecular_function	structural molecule activity
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0005794	cellular_component	Golgi apparatus
K	0005829	cellular_component	cytosol
K	0005886	cellular_component	plasma membrane
K	0006826	biological_process	iron ion transport
K	0006879	biological_process	intracellular iron ion homeostasis
K	0006955	biological_process	immune response
K	0006968	biological_process	cellular defense response
K	0007608	biological_process	sensory perception of smell
K	0007611	biological_process	learning or memory
K	0009897	cellular_component	external side of plasma membrane
K	0010977	biological_process	negative regulation of neuron projection development
K	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
K	0030670	cellular_component	phagocytic vesicle membrane
K	0033077	biological_process	T cell differentiation in thymus
K	0034756	biological_process	regulation of iron ion transport
K	0042026	biological_process	protein refolding
K	0042612	cellular_component	MHC class I protein complex
K	0042802	molecular_function	identical protein binding
K	0042803	molecular_function	protein homodimerization activity
K	0042824	cellular_component	MHC class I peptide loading complex
K	0045646	biological_process	regulation of erythrocyte differentiation
K	0048260	biological_process	positive regulation of receptor-mediated endocytosis
K	0050680	biological_process	negative regulation of epithelial cell proliferation
K	0050768	biological_process	negative regulation of neurogenesis
K	0051289	biological_process	protein homotetramerization
K	0060586	biological_process	multicellular organismal-level iron ion homeostasis
K	0071281	biological_process	cellular response to iron ion
K	0071283	biological_process	cellular response to iron(III) ion
K	0071316	biological_process	cellular response to nicotine
K	1990000	biological_process	amyloid fibril formation
K	1990712	cellular_component	HFE-transferrin receptor complex
K	2000774	biological_process	positive regulation of cellular senescence
K	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCRVYH

Chain	Residue	Details
A	TYR257-HIS263
B	TYR78-HIS84

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1136
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	GLY1-VAL285
D	GLY1-VAL285
G	GLY1-VAL285
J	GLY1-VAL285

---

site_id	SWS_FT_FI2
Number of Residues	84
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	ILE286-MET307
D	ILE286-MET307
G	ILE286-MET307
J	ILE286-MET307

---

site_id	SWS_FT_FI3
Number of Residues	120
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	LYS308-ALA338
D	LYS308-ALA338
G	LYS308-ALA338
J	LYS308-ALA338

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine; alternate => ECO:0000250|UniProtKB:P01900

Chain	Residue	Details
A	SER329
D	SER329
G	SER329
J	SER329

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P01900

Chain	Residue	Details
A	SER332
D	SER332
G	SER332
J	SER332

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:3980466, ECO:0000269|PubMed:7118212

Chain	Residue	Details
A	ASN86
D	ASN86
G	ASN86
J	ASN86

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305

Chain	Residue	Details
A	ASN176
D	ASN176
G	ASN176
J	ASN176

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:3980466

Chain	Residue	Details
A	ASN256
D	ASN256
G	ASN256
J	ASN256

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	CROSSLNK: Glycyl serine ester (Ser-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000305|PubMed:19951915

Chain	Residue	Details
A	SER329
D	SER329
G	SER329
J	SER329

---