1S70
Complex between protein ser/thr phosphatase-1 (delta) and the myosin phosphatase targeting subunit 1 (MYPT1)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| A | 0004722 | molecular_function | protein serine/threonine phosphatase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005977 | biological_process | glycogen metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017018 | molecular_function | myosin phosphatase activity |
| A | 0030155 | biological_process | regulation of cell adhesion |
| A | 0032922 | biological_process | circadian regulation of gene expression |
| A | 0042752 | biological_process | regulation of circadian rhythm |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050115 | molecular_function | myosin-light-chain-phosphatase activity |
| A | 0051301 | biological_process | cell division |
| A | 0072357 | cellular_component | PTW/PP1 phosphatase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 400 |
| Chain | Residue |
| A | ASP92 |
| A | ASN124 |
| A | HIS173 |
| A | HIS248 |
| A | MN401 |
| A | HOH415 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 401 |
| Chain | Residue |
| A | MN400 |
| A | HOH415 |
| A | ASP64 |
| A | HIS66 |
| A | ASP92 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PGE A 331 |
| Chain | Residue |
| A | VAL19 |
| A | GLY21 |
| A | CYS22 |
| A | PRO24 |
| A | GLY25 |
| A | LYS26 |
| A | THR70 |
| A | GLU77 |
| A | GLN99 |
| B | VAL264 |
Functional Information from PROSITE/UniProt
| site_id | PS00125 |
| Number of Residues | 6 |
| Details | SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE |
| Chain | Residue | Details |
| A | LEU121-GLU126 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-2007","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Black E.J.","Gillespie D.A."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 29 |
| Details | Repeat: {"description":"ANK 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 29 |
| Details | Repeat: {"description":"ANK 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 29 |
| Details | Repeat: {"description":"ANK 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 26 |
| Details | Repeat: {"description":"ANK 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 29 |
| Details | Repeat: {"description":"ANK 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 29 |
| Details | Repeat: {"description":"ANK 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | Region: {"description":"Important for interaction with PPP1CB"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1aui |
| Chain | Residue | Details |
| A | ASP95 | |
| A | HIS125 |
