1S4B

Crystal structure of human thimet oligopeptidase.

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0000209	biological_process	protein polyubiquitination
P	0004222	molecular_function	metalloendopeptidase activity
P	0005515	molecular_function	protein binding
P	0005737	cellular_component	cytoplasm
P	0005758	cellular_component	mitochondrial intermembrane space
P	0005829	cellular_component	cytosol
P	0006508	biological_process	proteolysis
P	0006518	biological_process	peptide metabolic process
P	0008233	molecular_function	peptidase activity
P	0008237	molecular_function	metallopeptidase activity
P	0016787	molecular_function	hydrolase activity
P	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN P 1

Chain	Residue
P	HIS473
P	HIS477
P	GLU502
P	HOH1163

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Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TYFHEFGHVM

Chain	Residue	Details
P	THR470-MET479

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:17251185

Chain	Residue	Details
P	PHE475

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:17251185

Chain	Residue	Details
P	GLU474
P	VAL478
P	GLN481

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
P	PRO17

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8C1A5

Chain	Residue	Details
P	LEU173

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
P	GLU258
P	LEU539

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q8C1A5

Chain	Residue	Details
P	VAL279

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