1S3S

Crystal structure of AAA ATPase p97/VCP ND1 in complex with p47 C

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0016887	molecular_function	ATP hydrolysis activity
B	0005524	molecular_function	ATP binding
B	0016887	molecular_function	ATP hydrolysis activity
C	0005524	molecular_function	ATP binding
C	0016887	molecular_function	ATP hydrolysis activity
D	0005524	molecular_function	ATP binding
D	0016887	molecular_function	ATP hydrolysis activity
E	0005524	molecular_function	ATP binding
E	0016887	molecular_function	ATP hydrolysis activity
F	0005524	molecular_function	ATP binding
F	0016887	molecular_function	ATP hydrolysis activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ADP A 800

Chain	Residue
A	ASP205
A	HIS384
A	GLY408
A	ALA409
A	HOH808
A	GLY207
A	GLY248
A	THR249
A	GLY250
A	LYS251
A	THR252
A	LEU253
A	ILE380

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP B 801

Chain	Residue
B	ASP205
B	VAL206
B	GLY207
B	GLY248
B	THR249
B	GLY250
B	LYS251
B	THR252
B	LEU253
B	ILE380
B	HIS384
B	GLY408
B	ALA409
F	ARG359

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ADP C 802

Chain	Residue
C	ASP205
C	VAL206
C	GLY207
C	GLY248
C	THR249
C	GLY250
C	LYS251
C	THR252
C	LEU253
C	ILE380
C	HIS384
C	GLY408
C	ALA409
C	HOH803
D	ARG359

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP D 803

Chain	Residue
D	ASP205
D	GLY207
D	GLY248
D	THR249
D	GLY250
D	LYS251
D	THR252
D	LEU253
D	HIS384
D	GLY408
D	ALA409
D	ALA412

---

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ADP E 804

Chain	Residue
C	ARG359
E	ASP205
E	GLY207
E	GLY248
E	THR249
E	GLY250
E	LYS251
E	THR252
E	LEU253
E	ILE380
E	HIS384
E	GLY408
E	ALA409

---

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ADP F 805

Chain	Residue
F	ASP205
F	GLY207
F	GLY248
F	THR249
F	GLY250
F	LYS251
F	THR252
F	LEU253
F	ILE380
F	HIS384
F	GLY408
F	ALA409
F	HOH810

---

Functional Information from PROSITE/UniProt

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. ViVMaATNrpnsIDpALr.R

Chain	Residue	Details
A	VAL341-ARG359

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11163219","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"14988733","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P55072","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P55072","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"N6,N6,N6-trimethyllysine; by VCPKMT","evidences":[{"source":"PubMed","id":"22948820","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P55072","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"UniProtKB","id":"P55072","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	154
Details	Domain: {"description":"UBX","evidences":[{"source":"PROSITE-ProRule","id":"PRU00215","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9UNZ2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---