1S3P

Crystal structure of rat alpha-parvalbumin S55D/E59D mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0005737	cellular_component	cytoplasm
A	0010467	biological_process	gene expression
A	0030424	cellular_component	axon
A	0032420	cellular_component	stereocilium
A	0032437	cellular_component	cuticular plate
A	0032991	cellular_component	protein-containing complex
A	0042802	molecular_function	identical protein binding
A	0043025	cellular_component	neuronal cell body
A	0043195	cellular_component	terminal bouton
A	0044877	molecular_function	protein-containing complex binding
A	0046872	molecular_function	metal ion binding
A	0090102	biological_process	cochlea development
A	0098976	biological_process	excitatory chemical synaptic transmission
A	0098977	biological_process	inhibitory chemical synaptic transmission

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 210

Chain	Residue
A	ASP51
A	ASP53
A	ASP55
A	PHE57
A	GLU62
A	HOH303

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 211

Chain	Residue
A	LYS96
A	GLU101
A	HOH304
A	ASP90
A	ASP92
A	ASP94

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 302

Chain	Residue
A	LYS45
A	HIS48
A	HOH331
A	HOH422
A	HOH428

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDKDGFIDedEL

Chain	Residue	Details
A	ASP51-LEU63
A	ASP90-PHE102

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	35
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	32
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11562941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15169955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15287728","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16101280","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8289291","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G33","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RWY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1S3P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XVJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3F45","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11562941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15169955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16101280","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8289291","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G33","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RWY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XVJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3F45","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11562941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15169955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15287728","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16101280","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8289291","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G33","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RWY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1S3P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XVJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3F45","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11562941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15169955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16101280","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8289291","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G33","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RWY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XVJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3F45","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11562941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15169955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15287728","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8289291","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G33","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RWY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1S3P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3F45","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---