1S2H
The Mad2 spindle checkpoint protein possesses two distinct natively folded states
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000070 | biological_process | mitotic sister chromatid segregation |
| A | 0000132 | biological_process | establishment of mitotic spindle orientation |
| A | 0000775 | cellular_component | chromosome, centromeric region |
| A | 0000776 | cellular_component | kinetochore |
| A | 0000922 | cellular_component | spindle pole |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005694 | cellular_component | chromosome |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0007094 | biological_process | mitotic spindle assembly checkpoint signaling |
| A | 0033597 | cellular_component | mitotic checkpoint complex |
| A | 0042177 | biological_process | negative regulation of protein catabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0044615 | cellular_component | nuclear pore nuclear basket |
| A | 0045930 | biological_process | negative regulation of mitotic cell cycle |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0051301 | biological_process | cell division |
| A | 0051660 | biological_process | establishment of centrosome localization |
| A | 0051783 | biological_process | regulation of nuclear division |
| A | 0072686 | cellular_component | mitotic spindle |
| A | 0090267 | biological_process | positive regulation of mitotic cell cycle spindle assembly checkpoint |
| A | 1901991 | biological_process | negative regulation of mitotic cell cycle phase transition |
| A | 1904667 | biological_process | negative regulation of ubiquitin protein ligase activity |
| A | 1990728 | cellular_component | mitotic spindle assembly checkpoint MAD1-MAD2 complex |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 183 |
| Details | Domain: {"description":"HORMA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00109","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Region: {"description":"Required for assuming the closed conformation and for interaction with CDC20"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Dhillon A.S.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"12574116","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"12574116","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
