1S1Q

TSG101(UEV) domain in complex with Ubiquitin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015031	biological_process	protein transport
A	0036211	biological_process	protein modification process
C	0015031	biological_process	protein transport
C	0036211	biological_process	protein modification process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CU C 9001

Chain	Residue
C	LYS101
C	HIS102
C	GLU138
C	HOH9042
C	HOH9086
D	GLU34

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU A 9002

Chain	Residue
B	GLU34
B	HOH9015
A	HIS102
A	GLU138
A	HOH9023

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CU B 9003

Chain	Residue
A	HIS115
A	HOH9109
B	ASP32

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU D 9004

Chain	Residue
C	HIS115
D	ASP32
D	HOH9005
D	HOH9060
D	HOH9061

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 502

Chain	Residue
C	LYS16
C	ARG18
C	ASP19
C	HOH9087

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 503

Chain	Residue
A	LYS16
A	ARG18
A	ASP19
A	HOH9065

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 504

Chain	Residue
A	GLY100
A	LYS101
B	THR7
B	THR9
B	GLY10

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 505

Chain	Residue
C	THR92
C	SER93
C	HOH9082
D	ASN60

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACY C 510

Chain	Residue
C	ILE70
C	PRO139
C	PRO140
C	VAL141

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACY D 511

Chain	Residue
D	LYS27
D	PRO38
D	ASP39
D	ASP52
D	HOH9037

---

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
B	LYS27-ASP52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Interacts with activating enzyme

Chain	Residue	Details
B	ARG54
B	ARG72
D	ARG54
D	ARG72

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Essential for function

Chain	Residue	Details
B	HIS68
D	HIS68

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291

Chain	Residue	Details
B	SER65
D	SER65

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457

Chain	Residue	Details
B	THR66
D	THR66

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742

Chain	Residue	Details
B	GLY76
D	GLY76

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603

Chain	Residue	Details
B	LYS6
D	LYS6

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Chain	Residue	Details
B	GLY76
D	GLY76

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144

Chain	Residue	Details
B	LYS11
B	LYS48
D	LYS11
D	LYS48

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860

Chain	Residue	Details
B	LYS27
D	LYS27

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127

Chain	Residue	Details
B	LYS29
D	LYS29

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577

Chain	Residue	Details
B	LYS33
D	LYS33

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106

Chain	Residue	Details
B	LYS63
D	LYS63

---