1RZT

Crystal structure of DNA polymerase lambda complexed with a two nucleotide gap DNA molecule

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034061	molecular_function	DNA polymerase activity
E	0003677	molecular_function	DNA binding
E	0003887	molecular_function	DNA-directed DNA polymerase activity
E	0006281	biological_process	DNA repair
E	0016779	molecular_function	nucleotidyltransferase activity
E	0034061	molecular_function	DNA polymerase activity
I	0003677	molecular_function	DNA binding
I	0003887	molecular_function	DNA-directed DNA polymerase activity
I	0006281	biological_process	DNA repair
I	0016779	molecular_function	nucleotidyltransferase activity
I	0034061	molecular_function	DNA polymerase activity
M	0003677	molecular_function	DNA binding
M	0003887	molecular_function	DNA-directed DNA polymerase activity
M	0006281	biological_process	DNA repair
M	0016779	molecular_function	nucleotidyltransferase activity
M	0034061	molecular_function	DNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 2001

Chain	Residue
A	SER339
A	ILE341
A	ALA344
A	HOH2092
C	DG5
C	HOH52

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA E 2002

Chain	Residue
G	DG5
G	HOH359
G	HOH360
E	SER339
E	ILE341
E	ALA344

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA I 2003

Chain	Residue
I	SER339
I	ILE341
I	ALA344
K	DG5
K	HOH407
K	HOH578

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA M 2005

Chain	Residue
M	SER339
M	ILE341
M	ALA344
O	DG5
O	HOH6
O	HOH7

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA M 2006

Chain	Residue
M	CYS300
M	ILE302
M	ILE305
M	HOH2930
P	DC3
P	HOH468

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA F 2007

Chain	Residue
F	HOH1008
F	HOH1009
F	HOH1010
F	HOH1011
F	HOH1012

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA A 2008

Chain	Residue
A	TYR267
A	GLN270

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA B 2009

Chain	Residue
B	HOH1013
B	HOH1014
B	HOH1015
B	HOH1016

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA J 2010

Chain	Residue
J	HOH1017
J	HOH1018

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA J 2011

Chain	Residue
J	HOH1019
J	HOH1020
J	HOH1021

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO M 2801

Chain	Residue
E	HOH2111
M	GLN350

---

Functional Information from PROSITE/UniProt

site_id	PS00522
Number of Residues	20
Details	DNA_POLYMERASE_X DNA polymerase family X signature. GSYrRGkatCgDVDVLIthP

Chain	Residue	Details
A	GLY416-PRO435

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	224
Details	Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"14992725","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Region: {"description":"Involved in primer binding","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Schiff-base intermediate with DNA","evidences":[{"source":"PubMed","id":"11457865","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17475573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PFQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17475573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PFO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PFQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1jms

Chain	Residue	Details
A	ASP490

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1jms

Chain	Residue	Details
E	ASP490

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1jms

Chain	Residue	Details
I	ASP490

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1jms

Chain	Residue	Details
M	ASP490

---