1RYV

Three dimensional solution structure of the K27A MUTANT of sodium channels inhibitor HAINANTOXIN-IV BY 2D 1H-NMR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0008200	molecular_function	ion channel inhibitor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NH2 A 36

Chain	Residue
A	GLU34
A	ILE35

---

Functional Information from PROSITE/UniProt

site_id	PS60021
Number of Residues	30
Details	HWTX_1 Huwentoxin-1 family signature. CLgFgkgCnpsndqCCkssnlvCsrahRWC

Chain	Residue	Details
A	CYS2-CYS31

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	34
Details	Peptide: {"description":"Mu-theraphotoxin-Hhn1b 1","featureId":"PRO_0000400567","evidences":[{"source":"PubMed","id":"12827284","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14512091","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20192277","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Site: {"description":"Interacts with channel"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Isoleucine amide","evidences":[{"source":"PubMed","id":"14512091","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15201273","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---