1RYH
Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0007264 | biological_process | small GTPase-mediated signal transduction |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005525 | molecular_function | GTP binding |
| B | 0007264 | biological_process | small GTPase-mediated signal transduction |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 539 |
| Chain | Residue |
| A | THR17 |
| A | GNP538 |
| A | HOH540 |
| A | HOH609 |
| A | HOH625 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 1539 |
| Chain | Residue |
| B | HOH1612 |
| B | THR17 |
| B | GNP1538 |
| B | HOH1540 |
| B | HOH1541 |
| site_id | AC3 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE GNP A 538 |
| Chain | Residue |
| A | GLY12 |
| A | ALA13 |
| A | VAL14 |
| A | GLY15 |
| A | LYS16 |
| A | THR17 |
| A | CYS18 |
| A | PHE28 |
| A | GLY60 |
| A | LYS135 |
| A | ASP137 |
| A | LEU138 |
| A | SER177 |
| A | ALA178 |
| A | LEU179 |
| A | MG539 |
| A | HOH540 |
| A | HOH541 |
| A | HOH600 |
| A | HOH601 |
| A | HOH606 |
| A | HOH609 |
| A | HOH625 |
| A | HOH640 |
| B | HOH1690 |
| site_id | AC4 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE GNP B 1538 |
| Chain | Residue |
| B | GLY12 |
| B | ALA13 |
| B | VAL14 |
| B | GLY15 |
| B | LYS16 |
| B | THR17 |
| B | CYS18 |
| B | PHE28 |
| B | LYS135 |
| B | ASP137 |
| B | LEU138 |
| B | SER177 |
| B | ALA178 |
| B | LEU179 |
| B | MG1539 |
| B | HOH1540 |
| B | HOH1541 |
| B | HOH1550 |
| B | HOH1612 |
| B | HOH1614 |
| B | HOH1652 |
| B | HOH1663 |
| B | HOH1682 |
| B | HOH1683 |
| B | HOH1687 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:38332367, ECO:0007744|PDB:8Q0N |
| Chain | Residue | Details |
| A | GLY12 | |
| A | ALA59 | |
| A | LEU138 | |
| B | GLY12 | |
| B | ALA59 | |
| B | LEU138 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11090627, ECO:0000269|PubMed:38332367, ECO:0000269|PubMed:38355798, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR, ECO:0007744|PDB:8Q0N, ECO:0007744|PDB:8WEJ |
| Chain | Residue | Details |
| A | ALA13 | |
| B | THR17 | |
| B | CYS18 | |
| B | THR35 | |
| B | ALA178 | |
| B | LEU179 | |
| A | LYS16 | |
| A | THR17 | |
| A | CYS18 | |
| A | THR35 | |
| A | ALA178 | |
| A | LEU179 | |
| B | ALA13 | |
| B | LYS16 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11090627, ECO:0000269|PubMed:38332367, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR, ECO:0007744|PDB:8Q0N |
| Chain | Residue | Details |
| A | VAL14 | |
| B | GLU31 | |
| B | TYR32 | |
| B | PRO34 | |
| B | LYS135 | |
| B | ASP137 | |
| A | GLY15 | |
| A | GLU31 | |
| A | TYR32 | |
| A | PRO34 | |
| A | LYS135 | |
| A | ASP137 | |
| B | VAL14 | |
| B | GLY15 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11090627, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR |
| Chain | Residue | Details |
| A | GLY60 | |
| B | GLY60 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:38355798, ECO:0007744|PDB:8WEJ |
| Chain | Residue | Details |
| A | SER177 | |
| B | SER177 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538 |
| Chain | Residue | Details |
| A | TYR32 | |
| B | TYR32 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103 |
| Chain | Residue | Details |
| A | THR35 | |
| B | THR35 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:10617634 |
| Chain | Residue | Details |
| A | SER71 | |
| B | SER71 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P61585 |
| Chain | Residue | Details |
| A | ASP189 | |
| B | ASP189 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | LIPID: (Microbial infection) N6-palmitoyl lysine => ECO:0000269|PubMed:29074776 |
| Chain | Residue | Details |
| A | GLY183 | |
| A | LEU184 | |
| B | GLY183 | |
| B | LEU184 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | LIPID: S-geranylgeranyl cysteine => ECO:0000269|PubMed:1903399 |
| Chain | Residue | Details |
| A | ASP189 | |
| B | ASP189 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704 |
| Chain | Residue | Details |
| A | TYR32 | |
| B | TYR32 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB, and by P.sordellii toxin TcsL; alternate => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059 |
| Chain | Residue | Details |
| A | THR35 | |
| B | THR35 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:18093184, ECO:0000269|PubMed:38332367 |
| Chain | Residue | Details |
| A | LYS166 | |
| B | LYS166 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23512198 |
| Chain | Residue | Details |
| A | LYS185 | |
| B | LYS185 |
