1RXY
E. coli uridine phosphorylase: type-B native
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004850 | molecular_function | uridine phosphorylase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006218 | biological_process | uridine catabolic process |
| A | 0006974 | biological_process | DNA damage response |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0009164 | biological_process | nucleoside catabolic process |
| A | 0009166 | biological_process | nucleotide catabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0030955 | molecular_function | potassium ion binding |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0044206 | biological_process | UMP salvage |
| A | 0046050 | biological_process | UMP catabolic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004850 | molecular_function | uridine phosphorylase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006218 | biological_process | uridine catabolic process |
| B | 0006974 | biological_process | DNA damage response |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0009164 | biological_process | nucleoside catabolic process |
| B | 0009166 | biological_process | nucleotide catabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0030955 | molecular_function | potassium ion binding |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0044206 | biological_process | UMP salvage |
| B | 0046050 | biological_process | UMP catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 1001 |
| Chain | Residue |
| A | GLU49 |
| A | ILE69 |
| A | SER73 |
| B | GLU49 |
| B | ILE69 |
| B | SER73 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 4001 |
| Chain | Residue |
| A | HIS8 |
| A | GLY10 |
| A | SER4 |
| A | VAL6 |
| A | PHE7 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 6001 |
| Chain | Residue |
| A | ARG48 |
| A | HOH6147 |
| A | HOH6148 |
| A | HOH6149 |
| B | GLY26 |
| B | ARG91 |
| B | HOH3171 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 2001 |
| Chain | Residue |
| A | ARG115 |
| A | LEU116 |
| A | LEU121 |
| A | LEU126 |
| A | HOH6020 |
| A | HOH6021 |
| A | HOH6094 |
| A | HOH6104 |
| A | HOH6135 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 3001 |
| Chain | Residue |
| B | ARG115 |
| B | LEU116 |
| B | LEU126 |
| B | HIS179 |
| B | HOH3031 |
| B | HOH3034 |
| B | HOH3129 |
| B | HOH3142 |
| B | HOH3143 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 5001 |
| Chain | Residue |
| A | THR111 |
| A | ALA132 |
| A | THR137 |
| B | THR111 |
| B | ALA132 |
| B | THR137 |
Functional Information from PROSITE/UniProt
| site_id | PS01232 |
| Number of Residues | 16 |
| Details | PNP_UDP_1 Purine and other phosphorylases family 1 signature. StGIGgPStSIaveEL |
| Chain | Residue | Details |
| A | SER66-LEU81 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1t0u |
| Chain | Residue | Details |
| A | GLU80 | |
| A | HIS8 | |
| A | ARG223 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1t0u |
| Chain | Residue | Details |
| B | GLU80 | |
| B | HIS8 | |
| B | ARG223 |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 787 |
| Chain | Residue | Details |
| A | HIS8 | proton acceptor, proton donor |
| A | GLU80 | electrostatic stabiliser, polar interaction |
| A | ARG168 | proton acceptor, proton donor |
| A | ARG223 | electrostatic stabiliser, polar interaction |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 787 |
| Chain | Residue | Details |
| B | HIS8 | proton acceptor, proton donor |
| B | GLU80 | electrostatic stabiliser, polar interaction |
| B | ARG168 | proton acceptor, proton donor |
| B | ARG223 | electrostatic stabiliser, polar interaction |
