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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

1RXT

Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase.

Functional Information from GO Data
ChainGOidnamespacecontents
A0001701biological_processin utero embryonic development
A0004379molecular_functionglycylpeptide N-tetradecanoyltransferase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006499biological_processN-terminal protein myristoylation
A0016020cellular_componentmembrane
A0016740molecular_functiontransferase activity
A0016746molecular_functionacyltransferase activity
A0018008biological_processN-terminal peptidyl-glycine N-myristoylation
A0018030molecular_functionpeptidyl-lysine N6-myristoyltransferase activity
A0019107molecular_functionmyristoyltransferase activity
A0022400biological_processregulation of opsin-mediated signaling pathway
A0042180biological_processketone metabolic process
A0072657biological_processprotein localization to membrane
A1903749biological_processpositive regulation of establishment of protein localization to mitochondrion
B0001701biological_processin utero embryonic development
B0004379molecular_functionglycylpeptide N-tetradecanoyltransferase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006499biological_processN-terminal protein myristoylation
B0016020cellular_componentmembrane
B0016740molecular_functiontransferase activity
B0016746molecular_functionacyltransferase activity
B0018008biological_processN-terminal peptidyl-glycine N-myristoylation
B0018030molecular_functionpeptidyl-lysine N6-myristoyltransferase activity
B0019107molecular_functionmyristoyltransferase activity
B0022400biological_processregulation of opsin-mediated signaling pathway
B0042180biological_processketone metabolic process
B0072657biological_processprotein localization to membrane
B1903749biological_processpositive regulation of establishment of protein localization to mitochondrion
C0001701biological_processin utero embryonic development
C0004379molecular_functionglycylpeptide N-tetradecanoyltransferase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006499biological_processN-terminal protein myristoylation
C0016020cellular_componentmembrane
C0016740molecular_functiontransferase activity
C0016746molecular_functionacyltransferase activity
C0018008biological_processN-terminal peptidyl-glycine N-myristoylation
C0018030molecular_functionpeptidyl-lysine N6-myristoyltransferase activity
C0019107molecular_functionmyristoyltransferase activity
C0022400biological_processregulation of opsin-mediated signaling pathway
C0042180biological_processketone metabolic process
C0072657biological_processprotein localization to membrane
C1903749biological_processpositive regulation of establishment of protein localization to mitochondrion
D0001701biological_processin utero embryonic development
D0004379molecular_functionglycylpeptide N-tetradecanoyltransferase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006499biological_processN-terminal protein myristoylation
D0016020cellular_componentmembrane
D0016740molecular_functiontransferase activity
D0016746molecular_functionacyltransferase activity
D0018008biological_processN-terminal peptidyl-glycine N-myristoylation
D0018030molecular_functionpeptidyl-lysine N6-myristoyltransferase activity
D0019107molecular_functionmyristoyltransferase activity
D0022400biological_processregulation of opsin-mediated signaling pathway
D0042180biological_processketone metabolic process
D0072657biological_processprotein localization to membrane
D1903749biological_processpositive regulation of establishment of protein localization to mitochondrion
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CO C 990
ChainResidue
CLEU276
CPHE298
CPHE326
CTYR352
CVAL354
site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 B 901
ChainResidue
BPHE314
BLYS391
site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 902
ChainResidue
BARG239
ALYS176
AARG178
site_idAC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 A 903
ChainResidue
AASN426
ALYS428
site_idAC5
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SO4 C 904
ChainResidue
CPRO376
Functional Information from PROSITE/UniProt
site_idPS00975
Number of Residues9
DetailsNMT_1 Myristoyl-CoA:protein N-myristoyltransferase signature 1. EINFLCvHK
ChainResidueDetails
AGLU167-LYS175
site_idPS00976
Number of Residues7
DetailsNMT_2 Myristoyl-CoA:protein N-myristoyltransferase signature 2. KFGiGDG
ChainResidueDetails
ALYS412-GLY418
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32103017","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25255805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32103017","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32111831","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25255805","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25255805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32111831","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}
ChainResidueDetails

242842

PDB entries from 2025-10-08

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