Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1RXT

Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001701	biological_process	in utero embryonic development
A	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006499	biological_process	N-terminal protein myristoylation
A	0016020	cellular_component	membrane
A	0016746	molecular_function	acyltransferase activity
A	0018008	biological_process	N-terminal peptidyl-glycine N-myristoylation
A	0018030	molecular_function	peptidyl-lysine N6-myristoyltransferase activity
A	0019107	molecular_function	myristoyltransferase activity
A	0022400	biological_process	regulation of opsin-mediated signaling pathway
A	0042180	biological_process	cellular ketone metabolic process
A	0072657	biological_process	protein localization to membrane
A	1903749	biological_process	positive regulation of establishment of protein localization to mitochondrion
B	0001701	biological_process	in utero embryonic development
B	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006499	biological_process	N-terminal protein myristoylation
B	0016020	cellular_component	membrane
B	0016746	molecular_function	acyltransferase activity
B	0018008	biological_process	N-terminal peptidyl-glycine N-myristoylation
B	0018030	molecular_function	peptidyl-lysine N6-myristoyltransferase activity
B	0019107	molecular_function	myristoyltransferase activity
B	0022400	biological_process	regulation of opsin-mediated signaling pathway
B	0042180	biological_process	cellular ketone metabolic process
B	0072657	biological_process	protein localization to membrane
B	1903749	biological_process	positive regulation of establishment of protein localization to mitochondrion
C	0001701	biological_process	in utero embryonic development
C	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006499	biological_process	N-terminal protein myristoylation
C	0016020	cellular_component	membrane
C	0016746	molecular_function	acyltransferase activity
C	0018008	biological_process	N-terminal peptidyl-glycine N-myristoylation
C	0018030	molecular_function	peptidyl-lysine N6-myristoyltransferase activity
C	0019107	molecular_function	myristoyltransferase activity
C	0022400	biological_process	regulation of opsin-mediated signaling pathway
C	0042180	biological_process	cellular ketone metabolic process
C	0072657	biological_process	protein localization to membrane
C	1903749	biological_process	positive regulation of establishment of protein localization to mitochondrion
D	0001701	biological_process	in utero embryonic development
D	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006499	biological_process	N-terminal protein myristoylation
D	0016020	cellular_component	membrane
D	0016746	molecular_function	acyltransferase activity
D	0018008	biological_process	N-terminal peptidyl-glycine N-myristoylation
D	0018030	molecular_function	peptidyl-lysine N6-myristoyltransferase activity
D	0019107	molecular_function	myristoyltransferase activity
D	0022400	biological_process	regulation of opsin-mediated signaling pathway
D	0042180	biological_process	cellular ketone metabolic process
D	0072657	biological_process	protein localization to membrane
D	1903749	biological_process	positive regulation of establishment of protein localization to mitochondrion

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CO C 990

Chain	Residue
C	LEU276
C	PHE298
C	PHE326
C	TYR352
C	VAL354

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 901

Chain	Residue
B	PHE314
B	LYS391

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 902

Chain	Residue
B	ARG239
A	LYS176
A	ARG178

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 903

Chain	Residue
A	ASN426
A	LYS428

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 C 904

Chain	Residue
C	PRO376

Functional Information from PROSITE/UniProt

site_id	PS00975
Number of Residues	9
Details	NMT_1 Myristoyl-CoA:protein N-myristoyltransferase signature 1. EINFLCvHK

Chain	Residue	Details
A	GLU167-LYS175

site_id	PS00976
Number of Residues	7
Details	NMT_2 Myristoyl-CoA:protein N-myristoyltransferase signature 2. KFGiGDG

Chain	Residue	Details
A	LYS412-GLY418

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:25255805, ECO:0000269\|PubMed:32111831, ECO:0000269\|Ref.19

Chain	Residue	Details
A	GLN41
C	ARG181
C	VAL182
C	ALA183
D	GLN41
D	ARG181
D	VAL182
D	ALA183
A	ARG181
A	VAL182
A	ALA183
B	GLN41
B	ARG181
B	VAL182
B	ALA183
C	GLN41

site_id	SWS_FT_FI2
Number of Residues	20
Details	BINDING: BINDING => ECO:0000269\|PubMed:25255805, ECO:0000269\|PubMed:32103017, ECO:0000269\|PubMed:32111831, ECO:0000269\|Ref.19

Chain	Residue	Details
A	PHE42
B	SER179
C	PHE42
C	TRP43
C	LEU171
C	VAL173
C	SER179
D	PHE42
D	TRP43
D	LEU171
D	VAL173
A	TRP43
D	SER179
A	LEU171
A	VAL173
A	SER179
B	PHE42
B	TRP43
B	LEU171
B	VAL173

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:32103017

Chain	Residue	Details
A	PHE170
B	PHE170
C	PHE170
D	PHE170

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:25255805, ECO:0000269\|Ref.19

Chain	Residue	Details
A	CYS172
B	CYS172
C	CYS172
D	CYS172

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:O70310

Chain	Residue	Details
A	SER-46
B	SER-46
C	SER-46
D	SER-46

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:16964243, ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER-30
B	SER-30
C	SER-30
D	SER-30

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER6
B	SER6
C	SER6
D	SER6

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)