1RXT

Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006499	biological_process	N-terminal protein myristoylation
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0018008	biological_process	N-terminal peptidyl-glycine N-myristoylation
A	0018030	molecular_function	peptidyl-lysine N6-myristoyltransferase activity
A	0019107	molecular_function	myristoyltransferase activity
A	0022400	biological_process	regulation of opsin-mediated signaling pathway
A	0042180	biological_process	ketone metabolic process
A	0072657	biological_process	protein localization to membrane
A	1903749	biological_process	positive regulation of establishment of protein localization to mitochondrion
B	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006499	biological_process	N-terminal protein myristoylation
B	0016020	cellular_component	membrane
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0018008	biological_process	N-terminal peptidyl-glycine N-myristoylation
B	0018030	molecular_function	peptidyl-lysine N6-myristoyltransferase activity
B	0019107	molecular_function	myristoyltransferase activity
B	0022400	biological_process	regulation of opsin-mediated signaling pathway
B	0042180	biological_process	ketone metabolic process
B	0072657	biological_process	protein localization to membrane
B	1903749	biological_process	positive regulation of establishment of protein localization to mitochondrion
C	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006499	biological_process	N-terminal protein myristoylation
C	0016020	cellular_component	membrane
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0018008	biological_process	N-terminal peptidyl-glycine N-myristoylation
C	0018030	molecular_function	peptidyl-lysine N6-myristoyltransferase activity
C	0019107	molecular_function	myristoyltransferase activity
C	0022400	biological_process	regulation of opsin-mediated signaling pathway
C	0042180	biological_process	ketone metabolic process
C	0072657	biological_process	protein localization to membrane
C	1903749	biological_process	positive regulation of establishment of protein localization to mitochondrion
D	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006499	biological_process	N-terminal protein myristoylation
D	0016020	cellular_component	membrane
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0018008	biological_process	N-terminal peptidyl-glycine N-myristoylation
D	0018030	molecular_function	peptidyl-lysine N6-myristoyltransferase activity
D	0019107	molecular_function	myristoyltransferase activity
D	0022400	biological_process	regulation of opsin-mediated signaling pathway
D	0042180	biological_process	ketone metabolic process
D	0072657	biological_process	protein localization to membrane
D	1903749	biological_process	positive regulation of establishment of protein localization to mitochondrion

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CO C 990

Chain	Residue
C	LEU276
C	PHE298
C	PHE326
C	TYR352
C	VAL354

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 901

Chain	Residue
B	PHE314
B	LYS391

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 902

Chain	Residue
B	ARG239
A	LYS176
A	ARG178

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site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 903

Chain	Residue
A	ASN426
A	LYS428

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site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 C 904

Chain	Residue
C	PRO376

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Functional Information from PROSITE/UniProt

site_id	PS00975
Number of Residues	9
Details	NMT_1 Myristoyl-CoA:protein N-myristoyltransferase signature 1. EINFLCvHK

Chain	Residue	Details
A	GLU167-LYS175

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site_id	PS00976
Number of Residues	7
Details	NMT_2 Myristoyl-CoA:protein N-myristoyltransferase signature 2. KFGiGDG

Chain	Residue	Details
A	LYS412-GLY418

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32103017","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25255805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32103017","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32111831","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25255805","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25255805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32111831","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human type-I N-myristoyltransferase with bound myristoyl-CoA and inhibitor DDD90055.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}

Chain

Residue

Details

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