Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1RWY

CRYSTAL STRUCTURE OF RAT ALPHA-PARVALBUMIN AT 1.05 RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0005737	cellular_component	cytoplasm
A	0010467	biological_process	gene expression
A	0030424	cellular_component	axon
A	0032420	cellular_component	stereocilium
A	0032437	cellular_component	cuticular plate
A	0032991	cellular_component	protein-containing complex
A	0042802	molecular_function	identical protein binding
A	0043025	cellular_component	neuronal cell body
A	0043195	cellular_component	terminal bouton
A	0044877	molecular_function	protein-containing complex binding
A	0046872	molecular_function	metal ion binding
A	0090102	biological_process	cochlea development
A	0098976	biological_process	excitatory chemical synaptic transmission
A	0098977	biological_process	inhibitory chemical synaptic transmission
B	0005509	molecular_function	calcium ion binding
B	0005737	cellular_component	cytoplasm
B	0010467	biological_process	gene expression
B	0030424	cellular_component	axon
B	0032420	cellular_component	stereocilium
B	0032437	cellular_component	cuticular plate
B	0032991	cellular_component	protein-containing complex
B	0042802	molecular_function	identical protein binding
B	0043025	cellular_component	neuronal cell body
B	0043195	cellular_component	terminal bouton
B	0044877	molecular_function	protein-containing complex binding
B	0046872	molecular_function	metal ion binding
B	0090102	biological_process	cochlea development
B	0098976	biological_process	excitatory chemical synaptic transmission
B	0098977	biological_process	inhibitory chemical synaptic transmission
C	0005509	molecular_function	calcium ion binding
C	0005737	cellular_component	cytoplasm
C	0010467	biological_process	gene expression
C	0030424	cellular_component	axon
C	0032420	cellular_component	stereocilium
C	0032437	cellular_component	cuticular plate
C	0032991	cellular_component	protein-containing complex
C	0042802	molecular_function	identical protein binding
C	0043025	cellular_component	neuronal cell body
C	0043195	cellular_component	terminal bouton
C	0044877	molecular_function	protein-containing complex binding
C	0046872	molecular_function	metal ion binding
C	0090102	biological_process	cochlea development
C	0098976	biological_process	excitatory chemical synaptic transmission
C	0098977	biological_process	inhibitory chemical synaptic transmission

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 421

Chain	Residue
A	ASP51
A	ASP53
A	SER55
A	PHE57
A	GLU59
A	GLU62

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 422

Chain	Residue
A	ASP90
A	ASP92
A	ASP94
A	LYS96
A	GLU101
A	HOH535

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 423

Chain	Residue
B	ASP51
B	ASP53
B	SER55
B	PHE57
B	GLU59
B	GLU62

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 424

Chain	Residue
B	ASP90
B	ASP92
B	ASP94
B	LYS96
B	GLU101
B	HOH523

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 425

Chain	Residue
C	ASP51
C	ASP53
C	SER55
C	PHE57
C	GLU59
C	GLU62

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 426

Chain	Residue
C	ASP90
C	ASP92
C	ASP94
C	LYS96
C	GLU101
C	HOH534

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 431

Chain	Residue
A	LYS12
A	HIS26
A	THR84
A	ALA88
A	HOH475
A	HOH497
A	HOH552

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 432

Chain	Residue
A	LYS37
B	LYS12
B	HIS48
B	HOH503
B	HOH511
B	HOH546

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 433

Chain	Residue
A	LYS36
A	ALA107
A	HOH462
B	LYS54
B	HOH453

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 436

Chain	Residue
B	LYS28
B	HOH459
B	HOH532
C	SER78
C	ALA79

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NH4 C 461

Chain	Residue
C	LEU6
A	ASP53
A	GLU59
A	ASP61
C	THR3

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PG4 C 441

Chain	Residue
B	GLU108
C	LYS52
C	ASP61
C	SER65
C	ASP92
C	HOH477
C	HOH548

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACY A 451

Chain	Residue
A	LYS96
A	HOH571
B	LYS83
C	SER1
C	HOH486
C	HOH555

site_id	CD1
Number of Residues	6
Details

Chain	Residue
A	ASP51
A	ASP53
A	SER55
A	PHE57
A	GLU59
A	GLU62

site_id	CD2
Number of Residues	6
Details

Chain	Residue
B	PHE57
B	GLU59
B	GLU62
B	ASP51
B	ASP53
B	SER55

site_id	CD3
Number of Residues	6
Details

Chain	Residue
C	ASP51
C	ASP53
C	SER55
C	PHE57
C	GLU59
C	GLU62

site_id	EF1
Number of Residues	6
Details

Chain	Residue
A	ASP90
A	ASP92
A	ASP94
A	LYS96
A	HOH535
A	GLU101

site_id	EF2
Number of Residues	6
Details

Chain	Residue
B	ASP90
B	ASP92
B	ASP94
B	LYS96
B	HOH523
B	GLU101

site_id	EF3
Number of Residues	6
Details

Chain	Residue
C	ASP90
C	ASP92
C	ASP94
C	LYS96
C	HOH534
C	GLU101

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDKSGFIEedEL

Chain	Residue	Details
A	ASP51-LEU63
A	ASP90-PHE102

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	105
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	96
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11562941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15169955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15287728","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16101280","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8289291","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G33","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RWY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1S3P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XVJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3F45","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11562941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15169955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16101280","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8289291","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G33","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RWY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XVJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3F45","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11562941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15169955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15287728","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16101280","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8289291","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G33","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RWY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1S3P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XVJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3F45","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11562941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15169955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16101280","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8289291","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G33","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RWY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XVJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3F45","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11562941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15169955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15287728","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8289291","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G33","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RWY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1S3P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3F45","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)