1RV3
E75L MUTANT OF RABBIT CYTOSOLIC SERINE HYDROXYMETHYLTRANSFERASE, COMPLEX WITH GLYCINE
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000900 | molecular_function | mRNA regulatory element binding translation repressor activity |
A | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006544 | biological_process | glycine metabolic process |
A | 0006563 | biological_process | L-serine metabolic process |
A | 0006565 | biological_process | L-serine catabolic process |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0008270 | molecular_function | zinc ion binding |
A | 0009113 | biological_process | purine nucleobase biosynthetic process |
A | 0016740 | molecular_function | transferase activity |
A | 0017148 | biological_process | negative regulation of translation |
A | 0019264 | biological_process | glycine biosynthetic process from serine |
A | 0030170 | molecular_function | pyridoxal phosphate binding |
A | 0035999 | biological_process | tetrahydrofolate interconversion |
A | 0036094 | molecular_function | small molecule binding |
A | 0042802 | molecular_function | identical protein binding |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0046653 | biological_process | tetrahydrofolate metabolic process |
A | 0046655 | biological_process | folic acid metabolic process |
A | 0048027 | molecular_function | mRNA 5'-UTR binding |
A | 0050897 | molecular_function | cobalt ion binding |
A | 0051289 | biological_process | protein homotetramerization |
A | 0070905 | molecular_function | serine binding |
A | 1904482 | biological_process | cellular response to tetrahydrofolate |
A | 1990830 | biological_process | cellular response to leukemia inhibitory factor |
B | 0000900 | molecular_function | mRNA regulatory element binding translation repressor activity |
B | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
B | 0005634 | cellular_component | nucleus |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006544 | biological_process | glycine metabolic process |
B | 0006563 | biological_process | L-serine metabolic process |
B | 0006565 | biological_process | L-serine catabolic process |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0008270 | molecular_function | zinc ion binding |
B | 0009113 | biological_process | purine nucleobase biosynthetic process |
B | 0016740 | molecular_function | transferase activity |
B | 0017148 | biological_process | negative regulation of translation |
B | 0019264 | biological_process | glycine biosynthetic process from serine |
B | 0030170 | molecular_function | pyridoxal phosphate binding |
B | 0035999 | biological_process | tetrahydrofolate interconversion |
B | 0036094 | molecular_function | small molecule binding |
B | 0042802 | molecular_function | identical protein binding |
B | 0042803 | molecular_function | protein homodimerization activity |
B | 0046653 | biological_process | tetrahydrofolate metabolic process |
B | 0046655 | biological_process | folic acid metabolic process |
B | 0048027 | molecular_function | mRNA 5'-UTR binding |
B | 0050897 | molecular_function | cobalt ion binding |
B | 0051289 | biological_process | protein homotetramerization |
B | 0070905 | molecular_function | serine binding |
B | 1904482 | biological_process | cellular response to tetrahydrofolate |
B | 1990830 | biological_process | cellular response to leukemia inhibitory factor |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PO4 A 501 |
Chain | Residue |
A | SER53 |
A | HIS231 |
A | ARG402 |
A | PLP500 |
B | TYR73 |
B | TYR83 |
site_id | AC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PO4 B 601 |
Chain | Residue |
B | SER203 |
B | HIS231 |
B | LYS257 |
B | ARG402 |
B | PLP600 |
A | TYR73 |
A | TYR83 |
B | SER53 |
site_id | AC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GLY B 602 |
Chain | Residue |
A | TYR73 |
A | LEU75 |
A | TYR83 |
B | SER53 |
B | HIS231 |
B | LYS257 |
B | ARG402 |
B | PLP600 |
site_id | AC4 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE PLP A 500 |
Chain | Residue |
A | SER119 |
A | GLY120 |
A | SER121 |
A | HIS148 |
A | SER203 |
A | ASP228 |
A | ALA230 |
A | HIS231 |
A | THR254 |
A | HIS256 |
A | LYS257 |
A | PO4501 |
A | HOH515 |
B | TYR73 |
B | GLY303 |
site_id | AC5 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE PLP B 600 |
Chain | Residue |
A | TYR73 |
A | TYR118 |
A | GLY303 |
B | SER119 |
B | GLY120 |
B | SER121 |
B | HIS148 |
B | THR202 |
B | SER203 |
B | ASP228 |
B | ALA230 |
B | HIS231 |
B | THR254 |
B | HIS256 |
B | LYS257 |
B | PO4601 |
B | GLY602 |
Functional Information from PROSITE/UniProt
site_id | PS00096 |
Number of Residues | 17 |
Details | SHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. HVvTTTTHKTLrGCRAG |
Chain | Residue | Details |
A | HIS249-GLY265 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Nucleophile => ECO:0000305|PubMed:7358720 |
Chain | Residue | Details |
A | TYR205 | |
B | TYR205 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor => ECO:0000250 |
Chain | Residue | Details |
A | LYS257 | |
B | LYS257 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:3553178 |
Chain | Residue | Details |
A | THR3 | |
B | THR3 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: Deamidated asparagine; alternate => ECO:0000269|PubMed:2318867 |
Chain | Residue | Details |
A | GLY7 | |
B | GLY7 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:10387080 |
Chain | Residue | Details |
A | THR258 | |
B | THR258 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | CROSSLNK: Isoaspartyl glycine isopeptide (Asn-Gly); alternate => ECO:0000269|PubMed:2318867 |
Chain | Residue | Details |
A | GLY7 | |
A | ALA8 | |
B | GLY7 | |
B | ALA8 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1cs1 |
Chain | Residue | Details |
A | ARG81 |
site_id | CSA2 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1cs1 |
Chain | Residue | Details |
B | ARG81 |
site_id | MCSA1 |
Number of Residues | 6 |
Details | M-CSA 147 |
Chain | Residue | Details |
A | SER74 | steric locator |
A | GLY76 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
A | MET229 | electrostatic stabiliser |
A | THR255 | electrostatic stabiliser, hydrogen bond acceptor |
A | THR258 | covalently attached, electron pair acceptor, electron pair donor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
A | ALA264 | electrostatic stabiliser |
site_id | MCSA2 |
Number of Residues | 6 |
Details | M-CSA 147 |
Chain | Residue | Details |
B | SER74 | steric locator |
B | GLY76 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
B | MET229 | electrostatic stabiliser |
B | THR255 | electrostatic stabiliser, hydrogen bond acceptor |
B | THR258 | covalently attached, electron pair acceptor, electron pair donor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
B | ALA264 | electrostatic stabiliser |