1RUP

Crystal structure (G) of native cationic cyclization antibody 4C6 fab at pH 8.5 with a data set collected at APS beamline 19-ID

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BEZ H 601

Chain	Residue
H	ALA34
H	ASN35
H	LEU95
H	PRO230
L	TRP89
L	GLY91

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site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL H 611

Chain	Residue
H	THR186
H	LEU187
H	SER188
H	HOH651
H	HOH724
L	SER162
L	SER176
L	THR178
H	PHE174
H	PRO175
H	VAL177

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site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL H 612

Chain	Residue
H	GLN16
H	SER17
H	ASP32
H	TYR53
H	HOH626
H	HOH634
H	HOH850

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site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL H 613

Chain	Residue
H	SER120
H	VAL121
H	TYR122
H	SER215
H	VAL219
H	LYS221
H	HOH664
H	HOH675
L	GLU123

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site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL H 614

Chain	Residue
H	ARG71
H	ASP72
H	THR73
H	HOH836
L	LYS53
L	LEU54
L	HOH229

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR192-HIS198

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