Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046656 | biological_process | folic acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 161 |
| Chain | Residue |
| A | ASP95 |
| A | ASP97 |
| A | MG162 |
| A | APC171 |
| A | HOH207 |
| A | HOH249 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 162 |
| Chain | Residue |
| A | APC171 |
| A | HHR181 |
| A | HOH247 |
| A | ASP95 |
| A | ASP97 |
| A | MG161 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 163 |
| Chain | Residue |
| A | PRO114 |
| A | LYS119 |
| A | ASP139 |
| A | HOH221 |
| site_id | AC4 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE APC A 171 |
| Chain | Residue |
| A | LYS23 |
| A | GLN74 |
| A | ASP95 |
| A | ASP97 |
| A | ILE98 |
| A | ARG110 |
| A | LEU111 |
| A | THR112 |
| A | HIS115 |
| A | TYR116 |
| A | ARG121 |
| A | MG161 |
| A | MG162 |
| A | HHR181 |
| A | HOH204 |
| A | HOH207 |
| A | HOH210 |
| A | HOH216 |
| A | HOH227 |
| A | HOH230 |
| A | HOH234 |
| A | HOH247 |
| A | HOH249 |
| A | HOH257 |
| A | HOH262 |
| A | HOH265 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE HHR A 181 |
| Chain | Residue |
| A | THR42 |
| A | PRO43 |
| A | PRO44 |
| A | TYR53 |
| A | ASN55 |
| A | ASP95 |
| A | PHE123 |
| A | MG162 |
| A | APC171 |
| A | HOH224 |
| A | HOH247 |
| A | HOH260 |
| A | HOH281 |
Functional Information from PROSITE/UniProt
| site_id | PS00794 |
| Number of Residues | 12 |
| Details | HPPK 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. RgGPRtlDLDIM |
| Chain | Residue | Details |
| A | ARG82-MET99 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hka |
| Chain | Residue | Details |
| A | ARG92 | |
| A | ARG82 | |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 151 |
| Chain | Residue | Details |
| A | ARG82 | electrostatic stabiliser, hydrogen bond donor |
| A | ARG92 | electrostatic stabiliser, hydrogen bond donor |
| A | ASP95 | metal ligand |
| A | ASP97 | metal ligand |
