Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046656 | biological_process | folic acid biosynthetic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046656 | biological_process | folic acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 161 |
| Chain | Residue |
| A | ASP95 |
| A | ASP97 |
| A | MG162 |
| A | APC171 |
| A | HOH413 |
| A | HOH423 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 162 |
| Chain | Residue |
| A | APC171 |
| A | PH2181 |
| A | HOH403 |
| A | ASP95 |
| A | ASP97 |
| A | MG161 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 163 |
| Chain | Residue |
| A | LYS119 |
| A | PHE137 |
| A | PRO138 |
| A | ASP139 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 361 |
| Chain | Residue |
| B | ASP295 |
| B | ASP297 |
| B | MG362 |
| B | APC371 |
| B | HOH426 |
| B | HOH668 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 362 |
| Chain | Residue |
| B | ASP295 |
| B | ASP297 |
| B | MG361 |
| B | APC371 |
| B | PH2381 |
| B | HOH401 |
| site_id | AC6 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE APC A 171 |
| Chain | Residue |
| A | GLN74 |
| A | ASP95 |
| A | ASP97 |
| A | ILE98 |
| A | ARG110 |
| A | LEU111 |
| A | THR112 |
| A | VAL113 |
| A | HIS115 |
| A | TYR116 |
| A | ARG121 |
| A | MG161 |
| A | MG162 |
| A | PH2181 |
| A | HOH403 |
| A | HOH413 |
| A | HOH423 |
| A | HOH442 |
| A | HOH473 |
| A | HOH539 |
| A | HOH540 |
| A | HOH651 |
| A | HOH681 |
| A | HOH682 |
| A | HOH798 |
| A | HOH818 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PH2 A 181 |
| Chain | Residue |
| A | THR42 |
| A | PRO43 |
| A | TYR53 |
| A | ASN55 |
| A | ASP95 |
| A | PHE123 |
| A | MG162 |
| A | APC171 |
| A | HOH403 |
| A | HOH640 |
| A | HOH708 |
| A | HOH713 |
| A | HOH818 |
| site_id | AC8 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE APC B 371 |
| Chain | Residue |
| B | LEU270 |
| B | ASP295 |
| B | ASP297 |
| B | ILE298 |
| B | ARG310 |
| B | LEU311 |
| B | THR312 |
| B | HIS315 |
| B | TYR316 |
| B | ARG321 |
| B | HIS348 |
| B | MG361 |
| B | MG362 |
| B | PH2381 |
| B | HOH401 |
| B | HOH415 |
| B | HOH420 |
| B | HOH425 |
| B | HOH426 |
| B | HOH427 |
| B | HOH514 |
| B | HOH515 |
| B | HOH524 |
| B | HOH530 |
| B | HOH668 |
| B | HOH688 |
| B | HOH772 |
| site_id | AC9 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PH2 B 381 |
| Chain | Residue |
| B | ASP295 |
| B | PHE323 |
| B | MG362 |
| B | APC371 |
| B | HOH401 |
| B | HOH446 |
| B | HOH461 |
| B | HOH588 |
| B | THR242 |
| B | PRO243 |
| B | LEU245 |
| B | TYR253 |
| B | ASN255 |
Functional Information from PROSITE/UniProt
| site_id | PS00794 |
| Number of Residues | 12 |
| Details | HPPK 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. RgGPRtlDLDIM |
| Chain | Residue | Details |
| A | ARG82-MET99 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hka |
| Chain | Residue | Details |
| A | ARG92 | |
| A | ARG82 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hka |
| Chain | Residue | Details |
| B | ARG292 | |
| B | ARG282 | |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 151 |
| Chain | Residue | Details |
| A | ARG82 | electrostatic stabiliser, hydrogen bond donor |
| A | ARG92 | electrostatic stabiliser, hydrogen bond donor |
| A | ASP95 | metal ligand |
| A | ASP97 | metal ligand |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 151 |
| Chain | Residue | Details |
| B | ARG282 | electrostatic stabiliser, hydrogen bond donor |
| B | ARG292 | electrostatic stabiliser, hydrogen bond donor |
| B | ASP295 | metal ligand |
| B | ASP297 | metal ligand |
