Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046656 | biological_process | folic acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 161 |
| Chain | Residue |
| A | ASP95 |
| A | ASP97 |
| A | GOL172 |
| A | HOH219 |
| A | HOH396 |
| A | HOH397 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 162 |
| Chain | Residue |
| A | HOH392 |
| A | HOH401 |
| A | HOH402 |
| A | GLU141 |
| A | HOH306 |
| A | HOH390 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 163 |
| Chain | Residue |
| A | GLY26 |
| A | SER31 |
| A | HOH231 |
| A | HOH247 |
| A | HOH319 |
| A | HOH393 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 164 |
| Chain | Residue |
| A | LYS119 |
| A | PRO138 |
| A | ASP139 |
| A | HOH240 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 165 |
| Chain | Residue |
| A | PHE39 |
| A | GLN79 |
| A | LYS157 |
| A | HOH217 |
| A | HOH228 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL A 166 |
| Chain | Residue |
| A | ALA24 |
| A | ARG75 |
| A | HOH210 |
| A | HOH211 |
| A | HOH228 |
| A | HOH250 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 171 |
| Chain | Residue |
| A | GLU30 |
| A | SER31 |
| A | HIS32 |
| A | GLU61 |
| A | SER63 |
| A | GLU134 |
| A | HOH269 |
| A | HOH310 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 172 |
| Chain | Residue |
| A | ASP95 |
| A | MG161 |
| A | HOH219 |
| A | HOH255 |
| A | HOH355 |
| A | HOH371 |
| A | HOH388 |
| A | HOH396 |
| A | HOH397 |
Functional Information from PROSITE/UniProt
| site_id | PS00794 |
| Number of Residues | 12 |
| Details | HPPK 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. RgGPRtlDLDIM |
| Chain | Residue | Details |
| A | ARG82-MET99 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hka |
| Chain | Residue | Details |
| A | ARG92 | |
| A | ARG82 | |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 151 |
| Chain | Residue | Details |
| A | ARG82 | electrostatic stabiliser, hydrogen bond donor |
| A | ARG92 | electrostatic stabiliser, hydrogen bond donor |
| A | ASP95 | metal ligand |
| A | ASP97 | metal ligand |
