Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1RTP

REFINED X-RAY STRUCTURE OF RAT PARVALBUMIN, A MAMMALIAN ALPHA-LINEAGE PARVALBUMIN, AT 2.0 A RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0005509	molecular_function	calcium ion binding
1	0005737	cellular_component	cytoplasm
1	0010467	biological_process	gene expression
1	0030424	cellular_component	axon
1	0032420	cellular_component	stereocilium
1	0032437	cellular_component	cuticular plate
1	0032991	cellular_component	protein-containing complex
1	0042802	molecular_function	identical protein binding
1	0043025	cellular_component	neuronal cell body
1	0043195	cellular_component	terminal bouton
1	0044877	molecular_function	protein-containing complex binding
1	0046872	molecular_function	metal ion binding
1	0090102	biological_process	cochlea development
1	0098976	biological_process	excitatory chemical synaptic transmission
1	0098977	biological_process	inhibitory chemical synaptic transmission
2	0005509	molecular_function	calcium ion binding
2	0005737	cellular_component	cytoplasm
2	0010467	biological_process	gene expression
2	0030424	cellular_component	axon
2	0032420	cellular_component	stereocilium
2	0032437	cellular_component	cuticular plate
2	0032991	cellular_component	protein-containing complex
2	0042802	molecular_function	identical protein binding
2	0043025	cellular_component	neuronal cell body
2	0043195	cellular_component	terminal bouton
2	0044877	molecular_function	protein-containing complex binding
2	0046872	molecular_function	metal ion binding
2	0090102	biological_process	cochlea development
2	0098976	biological_process	excitatory chemical synaptic transmission
2	0098977	biological_process	inhibitory chemical synaptic transmission
3	0005509	molecular_function	calcium ion binding
3	0005737	cellular_component	cytoplasm
3	0010467	biological_process	gene expression
3	0030424	cellular_component	axon
3	0032420	cellular_component	stereocilium
3	0032437	cellular_component	cuticular plate
3	0032991	cellular_component	protein-containing complex
3	0042802	molecular_function	identical protein binding
3	0043025	cellular_component	neuronal cell body
3	0043195	cellular_component	terminal bouton
3	0044877	molecular_function	protein-containing complex binding
3	0046872	molecular_function	metal ion binding
3	0090102	biological_process	cochlea development
3	0098976	biological_process	excitatory chemical synaptic transmission
3	0098977	biological_process	inhibitory chemical synaptic transmission

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA 1 110

Chain	Residue
1	ASP51
1	ASP53
1	SER55
1	PHE57
1	GLU59
1	GLU62

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA 1 111

Chain	Residue
1	ASP90
1	ASP92
1	ASP94
1	LYS96
1	GLU101
1	HOH121

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA 2 110

Chain	Residue
2	ASP51
2	ASP53
2	SER55
2	PHE57
2	GLU59
2	GLU62

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA 2 111

Chain	Residue
2	ASP90
2	ASP92
2	ASP94
2	LYS96
2	GLU101
2	HOH148

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA 3 110

Chain	Residue
3	ASP51
3	ASP53
3	SER55
3	PHE57
3	GLU59
3	GLU62

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA 3 111

Chain	Residue
3	ASP90
3	ASP92
3	ASP94
3	LYS96
3	GLU101
3	HOH145

site_id	CA1
Number of Residues	6
Details

Chain	Residue
1	ASP51
1	ASP53
1	SER55
1	PHE57
1	GLU59
1	GLU62

site_id	CA2
Number of Residues	6
Details

Chain	Residue
1	LYS96
1	GLU101
1	HOH121
1	ASP90
1	ASP92
1	ASP94

site_id	CB1
Number of Residues	6
Details

Chain	Residue
2	ASP51
2	ASP53
2	SER55
2	PHE57
2	GLU59
2	GLU62

site_id	CB2
Number of Residues	6
Details

Chain	Residue
2	ASP90
2	ASP92
2	ASP94
2	LYS96
2	GLU101
1	HOH121

site_id	CC1
Number of Residues	6
Details

Chain	Residue
3	ASP51
3	ASP53
3	SER55
3	PHE57
3	GLU59
3	GLU62

site_id	CC2
Number of Residues	6
Details

Chain	Residue
3	ASP90
3	ASP92
3	ASP94
3	LYS96
3	GLU101
1	HOH121

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDKSGFIEedEL

Chain	Residue	Details
1	ASP51-LEU63
1	ASP90-PHE102

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	105
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	96
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11562941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15169955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15287728","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16101280","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8289291","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G33","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RWY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1S3P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XVJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3F45","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11562941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15169955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16101280","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8289291","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G33","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RWY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XVJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3F45","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11562941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15169955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15287728","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16101280","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8289291","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G33","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RWY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1S3P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XVJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3F45","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11562941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15169955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16101280","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8289291","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G33","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RWY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XVJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3F45","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11562941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15169955","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15287728","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622856","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8289291","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G33","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RTP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RWY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1S3P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3F45","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)