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1RTO

PROTON NMR ASSIGNMENTS AND SOLUTION CONFORMATION OF RANTES, A CHEMOKINE OF THE CC TYPE

Functional Information from GO Data
ChainGOidnamespacecontents
A0002407biological_processdendritic cell chemotaxis
A0002548biological_processmonocyte chemotaxis
A0002676biological_processregulation of chronic inflammatory response
A0004435molecular_functionphosphatidylinositol phospholipase C activity
A0004672molecular_functionprotein kinase activity
A0005125molecular_functioncytokine activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0006816biological_processcalcium ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0006887biological_processexocytosis
A0006935biological_processchemotaxis
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0007159biological_processleukocyte cell-cell adhesion
A0007186biological_processG protein-coupled receptor signaling pathway
A0007267biological_processcell-cell signaling
A0008009molecular_functionchemokine activity
A0009615biological_processresponse to virus
A0009636biological_processresponse to toxic substance
A0010759biological_processpositive regulation of macrophage chemotaxis
A0010820biological_processpositive regulation of T cell chemotaxis
A0014911biological_processpositive regulation of smooth muscle cell migration
A0016004molecular_functionphospholipase activator activity
A0030298molecular_functionreceptor signaling protein tyrosine kinase activator activity
A0030335biological_processpositive regulation of cell migration
A0031328biological_processpositive regulation of cellular biosynthetic process
A0031584biological_processactivation of phospholipase D activity
A0031726molecular_functionCCR1 chemokine receptor binding
A0031729molecular_functionCCR4 chemokine receptor binding
A0031730molecular_functionCCR5 chemokine receptor binding
A0033634biological_processpositive regulation of cell-cell adhesion mediated by integrin
A0034097biological_processresponse to cytokine
A0034112biological_processpositive regulation of homotypic cell-cell adhesion
A0034612biological_processresponse to tumor necrosis factor
A0035689biological_processchemokine (C-C motif) ligand 5 signaling pathway
A0042056molecular_functionchemoattractant activity
A0042102biological_processpositive regulation of T cell proliferation
A0042119biological_processneutrophil activation
A0042327biological_processpositive regulation of phosphorylation
A0042379molecular_functionchemokine receptor binding
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043922biological_processnegative regulation by host of viral transcription
A0044344biological_processcellular response to fibroblast growth factor stimulus
A0045070biological_processpositive regulation of viral genome replication
A0045071biological_processnegative regulation of viral genome replication
A0045089biological_processpositive regulation of innate immune response
A0045744biological_processnegative regulation of G protein-coupled receptor signaling pathway
A0045745biological_processpositive regulation of G protein-coupled receptor signaling pathway
A0045785biological_processpositive regulation of cell adhesion
A0045948biological_processpositive regulation of translational initiation
A0046817molecular_functionchemokine receptor antagonist activity
A0048020molecular_functionCCR chemokine receptor binding
A0048245biological_processeosinophil chemotaxis
A0048246biological_processmacrophage chemotaxis
A0048661biological_processpositive regulation of smooth muscle cell proliferation
A0050673biological_processepithelial cell proliferation
A0050679biological_processpositive regulation of epithelial cell proliferation
A0050796biological_processregulation of insulin secretion
A0050863biological_processregulation of T cell activation
A0050918biological_processpositive chemotaxis
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051928biological_processpositive regulation of calcium ion transport
A0060326biological_processcell chemotaxis
A0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
A0070098biological_processchemokine-mediated signaling pathway
A0070100biological_processnegative regulation of chemokine-mediated signaling pathway
A0070233biological_processnegative regulation of T cell apoptotic process
A0070234biological_processpositive regulation of T cell apoptotic process
A0071346biological_processcellular response to type II interferon
A0071347biological_processcellular response to interleukin-1
A0071356biological_processcellular response to tumor necrosis factor
A0090026biological_processpositive regulation of monocyte chemotaxis
A0097696biological_processcell surface receptor signaling pathway via STAT
A0098586biological_processcellular response to virus
A1904894biological_processpositive regulation of receptor signaling pathway via STAT
A2000110biological_processnegative regulation of macrophage apoptotic process
A2000406biological_processpositive regulation of T cell migration
A2000503biological_processpositive regulation of natural killer cell chemotaxis
B0002407biological_processdendritic cell chemotaxis
B0002548biological_processmonocyte chemotaxis
B0002676biological_processregulation of chronic inflammatory response
B0004435molecular_functionphosphatidylinositol phospholipase C activity
B0004672molecular_functionprotein kinase activity
B0005125molecular_functioncytokine activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0006816biological_processcalcium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0006887biological_processexocytosis
B0006935biological_processchemotaxis
B0006954biological_processinflammatory response
B0006955biological_processimmune response
B0007159biological_processleukocyte cell-cell adhesion
B0007186biological_processG protein-coupled receptor signaling pathway
B0007267biological_processcell-cell signaling
B0008009molecular_functionchemokine activity
B0009615biological_processresponse to virus
B0009636biological_processresponse to toxic substance
B0010759biological_processpositive regulation of macrophage chemotaxis
B0010820biological_processpositive regulation of T cell chemotaxis
B0014911biological_processpositive regulation of smooth muscle cell migration
B0016004molecular_functionphospholipase activator activity
B0030298molecular_functionreceptor signaling protein tyrosine kinase activator activity
B0030335biological_processpositive regulation of cell migration
B0031328biological_processpositive regulation of cellular biosynthetic process
B0031584biological_processactivation of phospholipase D activity
B0031726molecular_functionCCR1 chemokine receptor binding
B0031729molecular_functionCCR4 chemokine receptor binding
B0031730molecular_functionCCR5 chemokine receptor binding
B0033634biological_processpositive regulation of cell-cell adhesion mediated by integrin
B0034097biological_processresponse to cytokine
B0034112biological_processpositive regulation of homotypic cell-cell adhesion
B0034612biological_processresponse to tumor necrosis factor
B0035689biological_processchemokine (C-C motif) ligand 5 signaling pathway
B0042056molecular_functionchemoattractant activity
B0042102biological_processpositive regulation of T cell proliferation
B0042119biological_processneutrophil activation
B0042327biological_processpositive regulation of phosphorylation
B0042379molecular_functionchemokine receptor binding
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043922biological_processnegative regulation by host of viral transcription
B0044344biological_processcellular response to fibroblast growth factor stimulus
B0045070biological_processpositive regulation of viral genome replication
B0045071biological_processnegative regulation of viral genome replication
B0045089biological_processpositive regulation of innate immune response
B0045744biological_processnegative regulation of G protein-coupled receptor signaling pathway
B0045745biological_processpositive regulation of G protein-coupled receptor signaling pathway
B0045785biological_processpositive regulation of cell adhesion
B0045948biological_processpositive regulation of translational initiation
B0046817molecular_functionchemokine receptor antagonist activity
B0048020molecular_functionCCR chemokine receptor binding
B0048245biological_processeosinophil chemotaxis
B0048246biological_processmacrophage chemotaxis
B0048661biological_processpositive regulation of smooth muscle cell proliferation
B0050673biological_processepithelial cell proliferation
B0050679biological_processpositive regulation of epithelial cell proliferation
B0050796biological_processregulation of insulin secretion
B0050863biological_processregulation of T cell activation
B0050918biological_processpositive chemotaxis
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0051928biological_processpositive regulation of calcium ion transport
B0060326biological_processcell chemotaxis
B0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
B0070098biological_processchemokine-mediated signaling pathway
B0070100biological_processnegative regulation of chemokine-mediated signaling pathway
B0070233biological_processnegative regulation of T cell apoptotic process
B0070234biological_processpositive regulation of T cell apoptotic process
B0071346biological_processcellular response to type II interferon
B0071347biological_processcellular response to interleukin-1
B0071356biological_processcellular response to tumor necrosis factor
B0090026biological_processpositive regulation of monocyte chemotaxis
B0097696biological_processcell surface receptor signaling pathway via STAT
B0098586biological_processcellular response to virus
B1904894biological_processpositive regulation of receptor signaling pathway via STAT
B2000110biological_processnegative regulation of macrophage apoptotic process
B2000406biological_processpositive regulation of T cell migration
B2000503biological_processpositive regulation of natural killer cell chemotaxis
Functional Information from PROSITE/UniProt
site_idPS00472
Number of Residues42
DetailsSMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCFayiarp..LprahIkeYfytsgk..Csnp.AVVFvtrknrqv.CA
ChainResidueDetails
ACYS10-ALA51

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Cleavage; by DPP4
ChainResidueDetails
APRO2
BPRO2

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Methionine sulfoxide => ECO:0000269|PubMed:1380064
ChainResidueDetails
AMET67
BMET67

site_idSWS_FT_FI3
Number of Residues4
DetailsCARBOHYD: O-linked (GalNAc...) serine; partial => ECO:0000269|PubMed:1380064
ChainResidueDetails
ASER4
ASER5
BSER4
BSER5

226707

PDB entries from 2024-10-30

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