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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1RTM

TRIMERIC STRUCTURE OF A C-TYPE MANNOSE-BINDING PROTEIN

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0001867	biological_process	complement activation, lectin pathway
1	0005537	molecular_function	mannose binding
2	0001867	biological_process	complement activation, lectin pathway
2	0005537	molecular_function	mannose binding
3	0001867	biological_process	complement activation, lectin pathway
3	0005537	molecular_function	mannose binding

Functional Information from PDB Data

site_id	11
Number of Residues	7
Details

Chain	Residue
1	CA1
1	ASP161
1	GLU165
1	ASP188
1	GLU193
1	ASP194
1	HOH235

site_id	12
Number of Residues	7
Details

Chain	Residue
2	GLU165
2	ASP188
2	GLU193
2	ASP194
2	HOH243
2	CA1
2	ASP161

site_id	13
Number of Residues	7
Details

Chain	Residue
3	CA1
3	ASP161
3	GLU165
3	ASP188
3	GLU193
3	ASP194
3	HOH238

site_id	21
Number of Residues	7
Details

Chain	Residue
1	CA2
1	GLU185
1	ASN187
1	GLU193
1	ASN205
1	ASP206
1	GOL222

site_id	22
Number of Residues	7
Details

Chain	Residue
2	CA2
2	GLU185
2	ASN187
2	GLU193
2	ASN205
2	ASP206
2	GOL222

site_id	23
Number of Residues	7
Details

Chain	Residue
3	CA2
3	GLU185
3	ASN187
3	GLU193
3	ASN205
3	ASP206
3	GOL222

site_id	31
Number of Residues	7
Details

Chain	Residue
1	CA3
1	GLU165
1	ASP194
1	HOH233
1	HOH234
1	GOL10
1	GLU84

site_id	32
Number of Residues	5
Details

Chain	Residue
2	CA3
2	GLU165
2	ASP194
2	HOH233
2	HOH234

site_id	33
Number of Residues	7
Details

Chain	Residue
3	CA3
3	GLU165
3	ASP194
3	HOH225
1	HOH227
3	HOH333
3	GLU84

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA 1 1

Chain	Residue
1	ASP161
1	GLU165
1	ASP188
1	GLU193
1	ASP194
1	HOH235

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA 1 2

Chain	Residue
1	GLU185
1	ASN187
1	GLU193
1	ASN205
1	ASP206
1	GOL222

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA 1 3

Chain	Residue
1	GOL10
1	GLU84
1	GLU165
1	ASP194
1	HOH233
1	HOH234

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL 1 4

Chain	Residue
1	ASP194
1	CYS209

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA 2 1

Chain	Residue
2	ASP161
2	GLU165
2	ASP188
2	GLU193
2	ASP194
2	HOH243

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA 2 2

Chain	Residue
2	GLU185
2	ASN187
2	GLU193
2	ASN205
2	ASP206
2	GOL222

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA 2 3

Chain	Residue
2	GLU165
2	ASP194
2	HOH233
2	HOH234

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL 2 4

Chain	Residue
2	CYS209
2	ASP194
2	SER208

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA 3 1

Chain	Residue
3	ASP161
3	GLU165
3	ASP188
3	GLU193
3	ASP194
3	HOH238

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA 3 2

Chain	Residue
3	GLU185
3	ASN187
3	GLU193
3	ASN205
3	ASP206
3	GOL222

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA 3 3

Chain	Residue
1	HOH227
3	GLU84
3	GLU165
3	ASP194
3	HOH225
3	HOH333

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL 3 4

Chain	Residue
3	ASP194
3	CYS209
3	HOH322

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL 1 222

Chain	Residue
1	CA2
1	GOL13
1	GLU185
1	ASN187
1	GLU193
1	ASN205
1	ASP206
1	ILE207

site_id	BC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL 2 222

Chain	Residue
2	CA2
2	GLU185
2	ASN187
2	HIS189
2	GLU193
2	ASN205
2	ASP206
2	ILE207

site_id	BC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL 3 222

Chain	Residue
3	CA2
3	GLU185
3	ASN187
3	GLU193
3	ASN205
3	ASP206
3	ILE207
3	HOH349

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL 1 223

Chain	Residue
1	GOL15
1	PHE111
1	PHE219
1	HOH254
1	HOH311
1	HOH359

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL 2 5

Chain	Residue
1	LEU98
2	ASN96
2	PHE111
2	HOH226
2	HOH298
2	HOH335

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL 3 6

Chain	Residue
3	ASN96
3	PHE111
3	PHE219
3	HOH231
3	HOH309
3	HOH328

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL 1 7

Chain	Residue
1	LYS125
1	CYS128
1	SER129
1	THR134
1	VAL135
1	VAL171

site_id	CC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL 2 8

Chain	Residue
2	LYS97
2	ALA100
2	PHE101
2	LYS105
2	HOH227
2	HOH315
2	HOH335

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL 1 9

Chain	Residue
1	ALA83
1	ASN86
1	THR87
1	GLN167
1	HOH363

site_id	CC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL 1 10

Chain	Residue
1	CA3
1	ASN80
1	GLU84
1	ASP194
1	HOH226
1	HOH233
1	HOH234
1	HOH284
1	HOH285
1	HOH369
2	GLU82

site_id	CC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL 1 11

Chain	Residue
1	THR134
1	PRO220
1	HOH301
1	HOH365
1	HOH394
1	HOH395
3	LYS182
3	LYS183
3	ASP184

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL 3 12

Chain	Residue
3	ASN140
3	ALA141
3	TYR178

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL 1 13

Chain	Residue
1	ILE207
1	GOL222
1	HOH286
1	HOH327

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL 1 14

Chain	Residue
1	LYS182
1	GLU185
1	VAL199
1	ASN205

site_id	CC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL 1 15

Chain	Residue
1	GLU93
1	ASN96
1	LYS97
1	ALA100
1	LYS105
1	PHE111
1	GOL223
1	HOH274
1	HOH359

Functional Information from PROSITE/UniProt

site_id	PS00615
Number of Residues	23
Details	C_TYPE_LECTIN_1 C-type lectin domain signature. CVtivdngl.....WNDISCqasht.AVC

Chain	Residue	Details
1	CYS195-CYS217

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	285
Details	Domain: {"description":"C-type lectin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00040","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	24
Details	Region: {"description":"Calcium-dependent carbohydrate binding","evidences":[{"source":"PubMed","id":"11850428","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1436090","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9033386","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11850428","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1436090","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7704532","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9033386","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AFA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1AFB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1AFD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1BCH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1BCJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FIF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FIH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KMB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KX1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RTM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2KMB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2MSB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KMB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KMB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11850428","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1436090","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7704532","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9033386","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KMB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KWZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KX1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RTM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2KMB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2MSB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KMB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KMB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

246031

PDB entries from 2025-12-10

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