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1RT5

HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC10

Functional Information from GO Data
ChainGOidnamespacecontents
A0003676molecular_functionnucleic acid binding
A0003964molecular_functionRNA-directed DNA polymerase activity
A0004523molecular_functionRNA-DNA hybrid ribonuclease activity
A0006278biological_processRNA-templated DNA biosynthetic process
B0003964molecular_functionRNA-directed DNA polymerase activity
B0006278biological_processRNA-templated DNA biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PO4 A 1001
ChainResidue
AILE94
AHIS96
APRO97
ATRP229
AMET230

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE UC2 A 999
ChainResidue
ATYR181
ATYR188
ALEU234
AHIS235
ATYR318
ALEU100
ALYS101
ALYS103
AVAL179

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
BVAL111
BASP186
BLEU187

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Cleavage; by viral protease => ECO:0000250
ChainResidueDetails
BPRO1
ASER499

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Essential for RT p66/p51 heterodimerization => ECO:0000250
ChainResidueDetails
BTRP402
BGLU415

site_idSWS_FT_FI4
Number of Residues1
DetailsSITE: Cleavage; by viral protease => ECO:0000250
ChainResidueDetails
APRO1

site_idSWS_FT_FI5
Number of Residues2
DetailsSITE: Essential for RT p66/p51 heterodimerization => ECO:0000250
ChainResidueDetails
ATRP402
AGLU415

site_idSWS_FT_FI6
Number of Residues1
DetailsSITE: Cleavage; by viral protease; partial => ECO:0000250
ChainResidueDetails
ATYR441

Catalytic Information from CSA
site_idMCSA1
Number of Residues
DetailsM-CSA 175
ChainResidueDetails

226707

PDB entries from 2024-10-30

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