Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0006956 | biological_process | complement activation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 740 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 741 |
| Chain | Residue |
| A | HIS466 |
| A | NA748 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NA A 745 |
| Chain | Residue |
| A | LYS594 |
| A | GLN722 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NA A 746 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA A 748 |
| Chain | Residue |
| A | HIS322 |
| A | LYS323 |
| A | LEU324 |
| A | IOD741 |
| A | ALA290 |
| A | THR291 |
| A | TYR292 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 749 |
| Chain | Residue |
| A | SER253 |
| A | SER255 |
| A | THR328 |
| A | HOH945 |
| A | HOH946 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE DFP A 750 |
| Chain | Residue |
| A | GLU484 |
| A | HIS501 |
| A | THR669 |
| A | CYS670 |
| A | ARG671 |
| A | GLY672 |
| A | SER674 |
| A | SER693 |
| A | TRP694 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| A | LEU497-CYS502 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. NTcrGDSGGPLI |
| Chain | Residue | Details |
| A | ASN668-ILE679 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| A | HIS501 | |
| A | ASP551 | |
| A | SER674 | |
| Chain | Residue | Details |
| A | ASN260 | |
| Chain | Residue | Details |
| A | LYS266 | |
| Chain | Residue | Details |
| A | ASN353 | |
