1RJD
Structure of PPM1, a leucine carboxy methyltransferase involved in the regulation of protein phosphatase 2A activity
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005575 | cellular_component | cellular_component |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0010506 | biological_process | regulation of autophagy |
| A | 0018423 | molecular_function | protein C-terminal leucine carboxyl O-methyltransferase activity |
| A | 0032259 | biological_process | methylation |
| A | 0065003 | biological_process | protein-containing complex assembly |
| B | 0005575 | cellular_component | cellular_component |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0010506 | biological_process | regulation of autophagy |
| B | 0018423 | molecular_function | protein C-terminal leucine carboxyl O-methyltransferase activity |
| B | 0032259 | biological_process | methylation |
| B | 0065003 | biological_process | protein-containing complex assembly |
| C | 0005575 | cellular_component | cellular_component |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0010506 | biological_process | regulation of autophagy |
| C | 0018423 | molecular_function | protein C-terminal leucine carboxyl O-methyltransferase activity |
| C | 0032259 | biological_process | methylation |
| C | 0065003 | biological_process | protein-containing complex assembly |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 C 335 |
| Chain | Residue |
| C | ARG192 |
| C | SER224 |
| C | HIS330 |
| C | HIS331 |
| C | HIS332 |
| C | HIS333 |
| C | HIS334 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE SAM A 801 |
| Chain | Residue |
| A | THR8 |
| A | ASP9 |
| A | ALA12 |
| A | ARG81 |
| A | GLY105 |
| A | CYS106 |
| A | GLY107 |
| A | ASP128 |
| A | TYR129 |
| A | CYS174 |
| A | ASP175 |
| A | LEU176 |
| A | ASN177 |
| A | GLU201 |
| A | CYS202 |
| A | LEU203 |
| A | HOH810 |
| A | HOH811 |
| A | HOH838 |
| A | HOH864 |
| A | HOH913 |
| A | HOH1010 |
| A | ILE5 |
| A | GLN6 |
| site_id | AC3 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE SAM B 802 |
| Chain | Residue |
| B | ILE5 |
| B | GLN6 |
| B | THR8 |
| B | ASP9 |
| B | ALA12 |
| B | ARG81 |
| B | GLY105 |
| B | CYS106 |
| B | GLY107 |
| B | ASP128 |
| B | TYR129 |
| B | CYS174 |
| B | ASP175 |
| B | LEU176 |
| B | ASN177 |
| B | GLU201 |
| B | CYS202 |
| B | LEU203 |
| B | TYR206 |
| B | HOH809 |
| B | HOH811 |
| B | HOH823 |
| B | HOH847 |
| B | HOH863 |
| B | HOH877 |
| site_id | AC4 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE SAM C 803 |
| Chain | Residue |
| C | ILE5 |
| C | GLN6 |
| C | THR8 |
| C | ALA12 |
| C | ARG81 |
| C | GLY105 |
| C | CYS106 |
| C | GLY107 |
| C | ASP128 |
| C | TYR129 |
| C | CYS174 |
| C | ASP175 |
| C | LEU176 |
| C | ASN177 |
| C | GLU201 |
| C | CYS202 |
| C | LEU203 |
| C | TYR206 |
| C | HOH824 |
| C | HOH826 |
| C | HOH846 |
| C | HOH869 |
| C | HOH912 |
| C | HOH949 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BME A 804 |
| Chain | Residue |
| A | CYS202 |
| A | TYR206 |
| A | PRO233 |
| A | MET259 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BME B 805 |
| Chain | Residue |
| B | CYS202 |
| B | TYR206 |
| B | PRO233 |
| B | HOH978 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BME C 806 |
| Chain | Residue |
| C | CYS202 |
| C | TYR206 |
| C | PRO233 |
| C | MET259 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE BME A 807 |
| Chain | Residue |
| A | SER14 |
| A | CYS15 |
| A | ALA66 |
| A | SER70 |
| A | HOH960 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BME B 808 |
| Chain | Residue |
| B | SER70 |
| B | MET74 |
| B | CYS15 |
| B | ALA66 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE BME C 809 |
| Chain | Residue |
| C | CYS15 |
| C | ALA66 |
| C | SER70 |
| C | MET74 |
| C | HOH1026 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 15 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ARG81 | |
| B | GLU201 | |
| C | ARG81 | |
| C | GLY105 | |
| C | ASP128 | |
| C | ASP175 | |
| C | GLU201 | |
| A | GLY105 | |
| A | ASP128 | |
| A | ASP175 | |
| A | GLU201 | |
| B | ARG81 | |
| B | GLY105 | |
| B | ASP128 | |
| B | ASP175 |
