1RI2

Structure and mechanism of mRNA cap (guanine N-7) methyltransferase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
A	0005634	cellular_component	nucleus
A	0006370	biological_process	7-methylguanosine mRNA capping
A	0008168	molecular_function	methyltransferase activity
A	0032259	biological_process	methylation
A	0106005	biological_process	RNA 5'-cap (guanine-N7)-methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GTG A 299

Chain	Residue
A	ASN50
A	TYR284
A	HOH307
A	HOH321
A	LYS75
A	GLY77
A	PHE141
A	HIS144
A	PRO175
A	PHE214
A	LEU216
A	GLU225

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
A	ASN50

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00895

Chain	Residue	Details
A	LYS54
A	GLY72
A	ASP94

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site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250|UniProtKB:O43148

Chain	Residue	Details
A	ASP122
A	GLN140
A	TYR145

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site_id	SWS_FT_FI4
Number of Residues	6
Details	SITE: mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00895

Chain	Residue	Details
A	LYS75
A	LYS81
A	ARG106
A	HIS144
A	GLU225
A	TYR284

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1qam

Chain	Residue	Details
A	GLN140
A	GLY72
A	ASP94

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