1RG1
Crystal structure of human Tyrosyl-DNA Phosphodiesterase complexed with vanadate, octopamine, and tetranucleotide AGTT
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE VO4 A 699 |
| Chain | Residue |
| A | HIS263 |
| A | LYS265 |
| A | ASN283 |
| A | HIS493 |
| A | LYS495 |
| A | ASN516 |
| A | OTS997 |
| D | DT806 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE VO4 B 699 |
| Chain | Residue |
| B | LYS265 |
| B | ASN283 |
| B | HIS493 |
| B | LYS495 |
| B | ASN516 |
| B | HOH676 |
| B | OTS998 |
| F | DT806 |
| B | HIS263 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SPM A 999 |
| Chain | Residue |
| A | MET604 |
| A | TRP605 |
| A | VAL606 |
| A | PRO607 |
| B | THR449 |
| B | LEU451 |
| B | THR600 |
| B | HIS601 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE OTS A 997 |
| Chain | Residue |
| A | TYR204 |
| A | GLY458 |
| A | SER459 |
| A | PRO461 |
| A | HIS493 |
| A | VO4699 |
| A | HOH706 |
| D | DT806 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE OTS B 998 |
| Chain | Residue |
| B | TYR204 |
| B | ASN283 |
| B | GLY458 |
| B | SER459 |
| B | HIS493 |
| B | HOH676 |
| B | VO4699 |
| F | DT806 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Region: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"12470949","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"12470949","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15111055","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"12470949","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15111055","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12470949","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"12470949","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
