1RF6

Structural Studies of Streptococcus pneumoniae EPSP Synthase in S3P-GLP Bound State

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003866	molecular_function	3-phosphoshikimate 1-carboxyvinyltransferase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0008652	biological_process	amino acid biosynthetic process
A	0009073	biological_process	aromatic amino acid family biosynthetic process
A	0009423	biological_process	chorismate biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
B	0003824	molecular_function	catalytic activity
B	0003866	molecular_function	3-phosphoshikimate 1-carboxyvinyltransferase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0008652	biological_process	amino acid biosynthetic process
B	0009073	biological_process	aromatic amino acid family biosynthetic process
B	0009423	biological_process	chorismate biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
C	0003824	molecular_function	catalytic activity
C	0003866	molecular_function	3-phosphoshikimate 1-carboxyvinyltransferase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0008652	biological_process	amino acid biosynthetic process
C	0009073	biological_process	aromatic amino acid family biosynthetic process
C	0009423	biological_process	chorismate biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
D	0003824	molecular_function	catalytic activity
D	0003866	molecular_function	3-phosphoshikimate 1-carboxyvinyltransferase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0008652	biological_process	amino acid biosynthetic process
D	0009073	biological_process	aromatic amino acid family biosynthetic process
D	0009423	biological_process	chorismate biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GPJ A 1428

Chain	Residue
A	LYS20
A	HIS384
A	ARG385
A	S3P1429
A	HOH1430
A	HOH1462
A	HOH1483
A	ASN90
A	GLY92
A	THR93
A	ARG120
A	GLN168
A	ASP312
A	GLU340
A	ARG343

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE S3P A 1429

Chain	Residue
A	LYS20
A	SER21
A	ARG25
A	THR93
A	SER166
A	ALA167
A	GLN168
A	ILE311
A	ASP312
A	LYS339
A	GPJ1428
A	HOH1448
A	HOH1483
A	HOH1499
A	HOH1515
A	HOH1542

---

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GPJ B 1528

Chain	Residue
B	LYS20
B	ASN90
B	GLY92
B	THR93
B	ARG120
B	GLN168
B	ASP312
B	GLU340
B	ARG343
B	HIS384
B	ARG385
B	S3P1529
B	HOH1530
B	HOH1582

---

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE S3P B 1529

Chain	Residue
B	LYS20
B	SER21
B	ARG25
B	THR93
B	SER166
B	ALA167
B	GLN168
B	ASP312
B	LYS339
B	GPJ1528
B	HOH1556
B	HOH1575
B	HOH1582
B	HOH1612
B	HOH1614

---

site_id	AC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GPJ C 1628

Chain	Residue
C	LYS20
C	ASN90
C	GLY92
C	THR93
C	ARG120
C	GLN168
C	ASP312
C	GLU340
C	ARG343
C	HIS384
C	ARG385
C	S3P1629
C	HOH1630
C	HOH1644
C	HOH1718

---

site_id	AC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE S3P C 1629

Chain	Residue
C	LYS20
C	SER21
C	ARG25
C	THR93
C	SER166
C	ALA167
C	GLN168
C	ARG193
C	ASP312
C	LYS339
C	GPJ1628
C	HOH1657
C	HOH1661
C	HOH1706
C	HOH1718
C	HOH1763

---

site_id	AC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GPJ D 1728

Chain	Residue
D	ARG343
D	HIS384
D	ARG385
D	S3P1729
D	HOH1730
D	HOH1756
D	HOH1787
D	LYS20
D	ASN90
D	GLY92
D	THR93
D	ARG120
D	GLN168
D	ASP312
D	GLU340

---

site_id	AC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE S3P D 1729

Chain	Residue
D	LYS20
D	SER21
D	ARG25
D	THR93
D	SER166
D	ALA167
D	GLN168
D	ARG193
D	ASP312
D	LYS339
D	GPJ1728
D	HOH1756
D	HOH1759
D	HOH1776
D	HOH1814

---

Functional Information from PROSITE/UniProt

site_id	PS00104
Number of Residues	15
Details	EPSP_SYNTHASE_1 EPSP synthase signature 1. LNmGNSGTSIRlIsG

Chain	Residue	Details
A	LEU86-GLY100

---

site_id	PS00885
Number of Residues	19
Details	EPSP_SYNTHASE_2 EPSP synthase signature 2. KvKETDRIqVVadaLnsMG

Chain	Residue	Details
A	LYS337-GLY355

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14763973","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14763973","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1RF6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---