1RF5

Structural Studies of Streptococcus pneumoniae EPSP Synthase in Unliganded State

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003866	molecular_function	3-phosphoshikimate 1-carboxyvinyltransferase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0008652	biological_process	amino acid biosynthetic process
A	0009073	biological_process	aromatic amino acid family biosynthetic process
A	0009423	biological_process	chorismate biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
B	0003824	molecular_function	catalytic activity
B	0003866	molecular_function	3-phosphoshikimate 1-carboxyvinyltransferase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0008652	biological_process	amino acid biosynthetic process
B	0009073	biological_process	aromatic amino acid family biosynthetic process
B	0009423	biological_process	chorismate biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
C	0003824	molecular_function	catalytic activity
C	0003866	molecular_function	3-phosphoshikimate 1-carboxyvinyltransferase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0008652	biological_process	amino acid biosynthetic process
C	0009073	biological_process	aromatic amino acid family biosynthetic process
C	0009423	biological_process	chorismate biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
D	0003824	molecular_function	catalytic activity
D	0003866	molecular_function	3-phosphoshikimate 1-carboxyvinyltransferase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0008652	biological_process	amino acid biosynthetic process
D	0009073	biological_process	aromatic amino acid family biosynthetic process
D	0009423	biological_process	chorismate biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups

Functional Information from PROSITE/UniProt

site_id	PS00104
Number of Residues	15
Details	EPSP_SYNTHASE_1 EPSP synthase signature 1. LNmGNSGTSIRlIsG

Chain	Residue	Details
A	LEU86-GLY100

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site_id	PS00885
Number of Residues	19
Details	EPSP_SYNTHASE_2 EPSP synthase signature 2. KvKETDRIqVVadaLnsMG

Chain	Residue	Details
A	LYS337-GLY355

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00210, ECO:0000305|PubMed:14763973

Chain	Residue	Details
A	ASP312
B	ASP312
C	ASP312
D	ASP312

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site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00210

Chain	Residue	Details
A	LYS20
B	GLN168
B	ARG343
B	ARG385
C	LYS20
C	GLY92
C	ARG120
C	GLN168
C	ARG343
C	ARG385
D	LYS20
A	GLY92
D	GLY92
D	ARG120
D	GLN168
D	ARG343
D	ARG385
A	ARG120
A	GLN168
A	ARG343
A	ARG385
B	LYS20
B	GLY92
B	ARG120

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site_id	SWS_FT_FI3
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:14763973, ECO:0007744|PDB:1RF6

Chain	Residue	Details
A	SER21
B	ALA167
B	ASP312
B	LYS339
C	SER21
C	ARG25
C	SER166
C	ALA167
C	ASP312
C	LYS339
D	SER21
A	ARG25
D	ARG25
D	SER166
D	ALA167
D	ASP312
D	LYS339
A	SER166
A	ALA167
A	ASP312
A	LYS339
B	SER21
B	ARG25
B	SER166

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