1RF2

Cholera Toxin B-Pentamer Complexed With Bivalent Nitrophenol-Galactoside Ligand BV4

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0005515	molecular_function	protein binding
D	0005534	molecular_function	galactose binding
D	0005576	cellular_component	extracellular region
D	0016020	cellular_component	membrane
D	0020002	cellular_component	host cell plasma membrane
D	0035821	biological_process	modulation of process of another organism
D	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
D	0042597	cellular_component	periplasmic space
D	0046812	molecular_function	host cell surface binding
D	0090729	molecular_function	toxin activity
D	1902494	cellular_component	catalytic complex
E	0005515	molecular_function	protein binding
E	0005534	molecular_function	galactose binding
E	0005576	cellular_component	extracellular region
E	0016020	cellular_component	membrane
E	0020002	cellular_component	host cell plasma membrane
E	0035821	biological_process	modulation of process of another organism
E	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
E	0042597	cellular_component	periplasmic space
E	0046812	molecular_function	host cell surface binding
E	0090729	molecular_function	toxin activity
E	1902494	cellular_component	catalytic complex
F	0005515	molecular_function	protein binding
F	0005534	molecular_function	galactose binding
F	0005576	cellular_component	extracellular region
F	0016020	cellular_component	membrane
F	0020002	cellular_component	host cell plasma membrane
F	0035821	biological_process	modulation of process of another organism
F	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
F	0042597	cellular_component	periplasmic space
F	0046812	molecular_function	host cell surface binding
F	0090729	molecular_function	toxin activity
F	1902494	cellular_component	catalytic complex
G	0005515	molecular_function	protein binding
G	0005534	molecular_function	galactose binding
G	0005576	cellular_component	extracellular region
G	0016020	cellular_component	membrane
G	0020002	cellular_component	host cell plasma membrane
G	0035821	biological_process	modulation of process of another organism
G	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
G	0042597	cellular_component	periplasmic space
G	0046812	molecular_function	host cell surface binding
G	0090729	molecular_function	toxin activity
G	1902494	cellular_component	catalytic complex
H	0005515	molecular_function	protein binding
H	0005534	molecular_function	galactose binding
H	0005576	cellular_component	extracellular region
H	0016020	cellular_component	membrane
H	0020002	cellular_component	host cell plasma membrane
H	0035821	biological_process	modulation of process of another organism
H	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
H	0042597	cellular_component	periplasmic space
H	0046812	molecular_function	host cell surface binding
H	0090729	molecular_function	toxin activity
H	1902494	cellular_component	catalytic complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE BV4 D 104

Chain	Residue
D	TYR12
D	HOH1352
D	HOH1481
E	GLY33
D	GLU51
D	GLN56
D	HIS57
D	GLN61
D	TRP88
D	ASN90
D	LYS91
D	HOH1133

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE BV4 E 105

Chain	Residue
E	TYR12
E	GLU51
E	GLN56
E	GLN61
E	TRP88
E	ASN90
E	LYS91
E	HOH1262
E	HOH1480
F	GLY33

---

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE BV4 F 106

Chain	Residue
F	TYR12
F	GLU51
F	GLN56
F	HIS57
F	GLN61
F	TRP88
F	ASN90
F	LYS91
F	HOH1049
F	HOH1152
G	GLY33

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE BV4 G 107

Chain	Residue
G	TYR12
G	GLU51
G	GLN56
G	HIS57
G	GLN61
G	TRP88
G	ASN90
G	LYS91
G	HOH1018
G	HOH1137
G	HOH1261
H	GLY33

---

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE BV4 H 108

Chain	Residue
D	GLY33
H	TYR12
H	GLU51
H	GLN56
H	HIS57
H	GLN61
H	TRP88
H	ASN90
H	LYS91
H	HOH1048
H	HOH1150
H	HOH1346
H	HOH1479

---

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TRS H 109

Chain	Residue
D	ARG35
F	ASN14
F	ASN89
F	ASN90
H	THR1
H	PRO2
H	ASP7
H	GLU11
H	HOH1075
H	HOH1496

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PGE H 110

Chain	Residue
D	LYS91
D	THR92
F	ASN89
F	ASN90
F	LYS91
F	THR92
H	THR1
H	HOH1472

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