1R8X
Crystal Structure of Mouse Glycine N-Methyltransferase (Tetragonal Form)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005542 | molecular_function | folic acid binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005977 | biological_process | glycogen metabolic process |
| A | 0006111 | biological_process | regulation of gluconeogenesis |
| A | 0006544 | biological_process | glycine metabolic process |
| A | 0006546 | biological_process | glycine catabolic process |
| A | 0006555 | biological_process | methionine metabolic process |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| A | 0016594 | molecular_function | glycine binding |
| A | 0017174 | molecular_function | glycine N-methyltransferase activity |
| A | 0018013 | biological_process | N-terminal peptidyl-glycine methylation |
| A | 0034708 | cellular_component | methyltransferase complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046500 | biological_process | S-adenosylmethionine metabolic process |
| A | 0050843 | biological_process | S-adenosylmethionine catabolic process |
| A | 0051289 | biological_process | protein homotetramerization |
| A | 1901052 | biological_process | sarcosine metabolic process |
| A | 1901054 | biological_process | sarcosine biosynthetic process |
| A | 1901605 | biological_process | alpha-amino acid metabolic process |
| A | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
| B | 0005542 | molecular_function | folic acid binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005977 | biological_process | glycogen metabolic process |
| B | 0006111 | biological_process | regulation of gluconeogenesis |
| B | 0006544 | biological_process | glycine metabolic process |
| B | 0006546 | biological_process | glycine catabolic process |
| B | 0006555 | biological_process | methionine metabolic process |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| B | 0016594 | molecular_function | glycine binding |
| B | 0017174 | molecular_function | glycine N-methyltransferase activity |
| B | 0018013 | biological_process | N-terminal peptidyl-glycine methylation |
| B | 0034708 | cellular_component | methyltransferase complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046500 | biological_process | S-adenosylmethionine metabolic process |
| B | 0050843 | biological_process | S-adenosylmethionine catabolic process |
| B | 0051289 | biological_process | protein homotetramerization |
| B | 1901052 | biological_process | sarcosine metabolic process |
| B | 1901054 | biological_process | sarcosine biosynthetic process |
| B | 1901605 | biological_process | alpha-amino acid metabolic process |
| B | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BME A 1146 |
| Chain | Residue |
| A | PRO144 |
| A | CYS146 |
| A | HIS214 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BME A 1246 |
| Chain | Residue |
| A | ALA213 |
| A | CYS246 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE TRS A 1247 |
| Chain | Residue |
| A | THR67 |
| A | ASP70 |
| A | LEU136 |
| A | SER139 |
| B | GLU15 |
| A | ASP62 |
| A | ALA64 |
| A | CYS65 |
| A | GLY66 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE BME B 2146 |
| Chain | Residue |
| B | CYS146 |
| B | HIS214 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BME B 2262 |
| Chain | Residue |
| B | ARG255 |
| B | GLY260 |
| B | CYS262 |
| B | HIS264 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE TRS B 2263 |
| Chain | Residue |
| A | GLU15 |
| B | ALA64 |
| B | CYS65 |
| B | GLY66 |
| B | THR67 |
| B | VAL69 |
| B | ASP70 |
| B | LEU136 |
| B | SER139 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 36 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P13255","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylvaline","evidences":[{"source":"UniProtKB","id":"P13255","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17242355","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1xva |
| Chain | Residue | Details |
| A | GLU15 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1xva |
| Chain | Residue | Details |
| B | GLU15 |
