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1R6H

Solution Structure of human PRL-3

Functional Information from GO Data
ChainGOidnamespacecontents
A0004721molecular_functionphosphoprotein phosphatase activity
A0004725molecular_functionprotein tyrosine phosphatase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005886cellular_componentplasma membrane
A0006355biological_processregulation of DNA-templated transcription
A0006470biological_processprotein dephosphorylation
A0007219biological_processNotch signaling pathway
A0009966biological_processregulation of signal transduction
A0016020cellular_componentmembrane
A0016311biological_processdephosphorylation
A0016787molecular_functionhydrolase activity
A0043117biological_processpositive regulation of vascular permeability
A0043542biological_processendothelial cell migration
A1900746biological_processregulation of vascular endothelial growth factor signaling pathway
A1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
A1904951biological_processpositive regulation of establishment of protein localization
A1990830biological_processcellular response to leukemia inhibitory factor
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton donor => ECO:0000305
ChainResidueDetails
AASP75

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160
ChainResidueDetails
ACYS107

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING:
ChainResidueDetails
AARG113

237735

PDB entries from 2025-06-18

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