Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1R5T

The Crystal Structure of Cytidine Deaminase CDD1, an Orphan C to U editase from Yeast

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004126	molecular_function	cytidine deaminase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006216	biological_process	cytidine catabolic process
A	0006217	biological_process	deoxycytidine catabolic process
A	0008270	molecular_function	zinc ion binding
A	0008655	biological_process	pyrimidine-containing compound salvage
A	0009972	biological_process	cytidine deamination
A	0016787	molecular_function	hydrolase activity
A	0034654	biological_process	nucleobase-containing compound biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0055086	biological_process	nucleobase-containing small molecule metabolic process
A	0072527	biological_process	pyrimidine-containing compound metabolic process
A	1901135	biological_process	carbohydrate derivative metabolic process
B	0003824	molecular_function	catalytic activity
B	0004126	molecular_function	cytidine deaminase activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006216	biological_process	cytidine catabolic process
B	0006217	biological_process	deoxycytidine catabolic process
B	0008270	molecular_function	zinc ion binding
B	0008655	biological_process	pyrimidine-containing compound salvage
B	0009972	biological_process	cytidine deamination
B	0016787	molecular_function	hydrolase activity
B	0034654	biological_process	nucleobase-containing compound biosynthetic process
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0055086	biological_process	nucleobase-containing small molecule metabolic process
B	0072527	biological_process	pyrimidine-containing compound metabolic process
B	1901135	biological_process	carbohydrate derivative metabolic process
C	0003824	molecular_function	catalytic activity
C	0004126	molecular_function	cytidine deaminase activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006216	biological_process	cytidine catabolic process
C	0006217	biological_process	deoxycytidine catabolic process
C	0008270	molecular_function	zinc ion binding
C	0008655	biological_process	pyrimidine-containing compound salvage
C	0009972	biological_process	cytidine deamination
C	0016787	molecular_function	hydrolase activity
C	0034654	biological_process	nucleobase-containing compound biosynthetic process
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0055086	biological_process	nucleobase-containing small molecule metabolic process
C	0072527	biological_process	pyrimidine-containing compound metabolic process
C	1901135	biological_process	carbohydrate derivative metabolic process
D	0003824	molecular_function	catalytic activity
D	0004126	molecular_function	cytidine deaminase activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006216	biological_process	cytidine catabolic process
D	0006217	biological_process	deoxycytidine catabolic process
D	0008270	molecular_function	zinc ion binding
D	0008655	biological_process	pyrimidine-containing compound salvage
D	0009972	biological_process	cytidine deamination
D	0016787	molecular_function	hydrolase activity
D	0034654	biological_process	nucleobase-containing compound biosynthetic process
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0055086	biological_process	nucleobase-containing small molecule metabolic process
D	0072527	biological_process	pyrimidine-containing compound metabolic process
D	1901135	biological_process	carbohydrate derivative metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 150

Chain	Residue
A	CYS61
A	CYS96
A	CYS99
A	HOH223

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 151

Chain	Residue
B	CYS61
B	CYS96
B	CYS99
B	HOH209

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 152

Chain	Residue
C	CYS96
C	CYS99
C	HOH198
C	CYS61

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 153

Chain	Residue
D	CYS61
D	CYS96
D	CYS99
D	HOH179

Functional Information from PROSITE/UniProt

site_id	PS00903
Number of Residues	43
Details	CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. CAErsAMiqvlmaghrsgwkcmvicgdsedqcvs......PCgv......CrqfI

Chain	Residue	Details
A	CYS61-ILE103

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor => ECO:0000250

Chain	Residue	Details
A	GLU63
B	GLU63
C	GLU63
D	GLU63

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ASN50
B	ASN50
C	ASN50
D	ASN50

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING:

Chain	Residue	Details
A	CYS61
D	CYS61
D	CYS96
D	CYS99
A	CYS96
A	CYS99
B	CYS61
B	CYS96
B	CYS99
C	CYS61
C	CYS96
C	CYS99

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ctt

Chain	Residue	Details
A	GLU63

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ctt

Chain	Residue	Details
B	GLU63

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ctt

Chain	Residue	Details
C	GLU63

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1ctt

Chain	Residue	Details
D	GLU63

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)