1R4W
Crystal structure of Mitochondrial class kappa glutathione transferase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004364 | molecular_function | glutathione transferase activity |
| A | 0004602 | molecular_function | glutathione peroxidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005777 | cellular_component | peroxisome |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030855 | biological_process | epithelial cell differentiation |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0004364 | molecular_function | glutathione transferase activity |
| B | 0004602 | molecular_function | glutathione peroxidase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0005777 | cellular_component | peroxisome |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030855 | biological_process | epithelial cell differentiation |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| C | 0004364 | molecular_function | glutathione transferase activity |
| C | 0004602 | molecular_function | glutathione peroxidase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005759 | cellular_component | mitochondrial matrix |
| C | 0005777 | cellular_component | peroxisome |
| C | 0006749 | biological_process | glutathione metabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0030855 | biological_process | epithelial cell differentiation |
| C | 0098869 | biological_process | cellular oxidant detoxification |
| D | 0004364 | molecular_function | glutathione transferase activity |
| D | 0004602 | molecular_function | glutathione peroxidase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005759 | cellular_component | mitochondrial matrix |
| D | 0005777 | cellular_component | peroxisome |
| D | 0006749 | biological_process | glutathione metabolic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016740 | molecular_function | transferase activity |
| D | 0030855 | biological_process | epithelial cell differentiation |
| D | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GSH A 301 |
| Chain | Residue |
| A | SER16 |
| A | SER200 |
| A | ASP201 |
| B | LYS62 |
| B | ARG202 |
| A | PRO17 |
| A | TYR18 |
| A | ASN53 |
| A | PHE181 |
| A | GLY182 |
| A | LEU183 |
| A | PHE198 |
| A | GLY199 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE GSH B 401 |
| Chain | Residue |
| A | LYS62 |
| A | ARG202 |
| B | SER16 |
| B | PRO17 |
| B | TYR18 |
| B | LEU44 |
| B | MET48 |
| B | ASN53 |
| B | GLY182 |
| B | LEU183 |
| B | PHE198 |
| B | GLY199 |
| B | SER200 |
| B | ASP201 |
| B | HOH560 |
| B | HOH669 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GSH C 801 |
| Chain | Residue |
| C | SER16 |
| C | PRO17 |
| C | TYR18 |
| C | GLY182 |
| C | LEU183 |
| C | SER200 |
| C | ASP201 |
| C | HOH765 |
| D | LYS62 |
| D | ARG202 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE GSH D 901 |
| Chain | Residue |
| C | LYS62 |
| C | ARG202 |
| D | SER16 |
| D | PRO17 |
| D | TYR18 |
| D | MET48 |
| D | PHE181 |
| D | GLY182 |
| D | LEU183 |
| D | PHE198 |
| D | GLY199 |
| D | SER200 |
| D | ASP201 |
| D | HOH763 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14717589 |
| Chain | Residue | Details |
| A | PRO17 | |
| C | GLN54 | |
| C | PRO184 | |
| C | ASP201 | |
| D | PRO17 | |
| D | GLN54 | |
| D | PRO184 | |
| D | ASP201 | |
| A | GLN54 | |
| A | PRO184 | |
| A | ASP201 | |
| B | PRO17 | |
| B | GLN54 | |
| B | PRO184 | |
| B | ASP201 | |
| C | PRO17 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9DCM2 |
| Chain | Residue | Details |
| A | LEU37 | |
| C | ASP50 | |
| C | ALA145 | |
| C | THR194 | |
| D | LEU37 | |
| D | ASP50 | |
| D | ALA145 | |
| D | THR194 | |
| A | ASP50 | |
| A | ALA145 | |
| A | THR194 | |
| B | LEU37 | |
| B | ASP50 | |
| B | ALA145 | |
| B | THR194 | |
| C | LEU37 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 28 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9DCM2 |
| Chain | Residue | Details |
| A | GLU69 | |
| B | LYS94 | |
| B | VAL117 | |
| B | ILE159 | |
| B | LEU168 | |
| B | TYR178 | |
| C | GLU69 | |
| C | GLN75 | |
| C | LYS94 | |
| C | VAL117 | |
| C | ILE159 | |
| A | GLN75 | |
| C | LEU168 | |
| C | TYR178 | |
| D | GLU69 | |
| D | GLN75 | |
| D | LYS94 | |
| D | VAL117 | |
| D | ILE159 | |
| D | LEU168 | |
| D | TYR178 | |
| A | LYS94 | |
| A | VAL117 | |
| A | ILE159 | |
| A | LEU168 | |
| A | TYR178 | |
| B | GLU69 | |
| B | GLN75 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9DCM2 |
| Chain | Residue | Details |
| A | ASP86 | |
| A | SER166 | |
| B | ASP86 | |
| B | SER166 | |
| C | ASP86 | |
| C | SER166 | |
| D | ASP86 | |
| D | SER166 |
