1R4W

Crystal structure of Mitochondrial class kappa glutathione transferase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001889	biological_process	liver development
A	0004364	molecular_function	glutathione transferase activity
A	0004602	molecular_function	glutathione peroxidase activity
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005777	cellular_component	peroxisome
A	0006749	biological_process	glutathione metabolic process
A	0010042	biological_process	response to manganese ion
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0030855	biological_process	epithelial cell differentiation
A	0046685	biological_process	response to arsenic-containing substance
A	0098869	biological_process	cellular oxidant detoxification
B	0001889	biological_process	liver development
B	0004364	molecular_function	glutathione transferase activity
B	0004602	molecular_function	glutathione peroxidase activity
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005777	cellular_component	peroxisome
B	0006749	biological_process	glutathione metabolic process
B	0010042	biological_process	response to manganese ion
B	0016491	molecular_function	oxidoreductase activity
B	0016740	molecular_function	transferase activity
B	0030855	biological_process	epithelial cell differentiation
B	0046685	biological_process	response to arsenic-containing substance
B	0098869	biological_process	cellular oxidant detoxification
C	0001889	biological_process	liver development
C	0004364	molecular_function	glutathione transferase activity
C	0004602	molecular_function	glutathione peroxidase activity
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005777	cellular_component	peroxisome
C	0006749	biological_process	glutathione metabolic process
C	0010042	biological_process	response to manganese ion
C	0016491	molecular_function	oxidoreductase activity
C	0016740	molecular_function	transferase activity
C	0030855	biological_process	epithelial cell differentiation
C	0046685	biological_process	response to arsenic-containing substance
C	0098869	biological_process	cellular oxidant detoxification
D	0001889	biological_process	liver development
D	0004364	molecular_function	glutathione transferase activity
D	0004602	molecular_function	glutathione peroxidase activity
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005777	cellular_component	peroxisome
D	0006749	biological_process	glutathione metabolic process
D	0010042	biological_process	response to manganese ion
D	0016491	molecular_function	oxidoreductase activity
D	0016740	molecular_function	transferase activity
D	0030855	biological_process	epithelial cell differentiation
D	0046685	biological_process	response to arsenic-containing substance
D	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GSH A 301

Chain	Residue
A	SER16
A	SER200
A	ASP201
B	LYS62
B	ARG202
A	PRO17
A	TYR18
A	ASN53
A	PHE181
A	GLY182
A	LEU183
A	PHE198
A	GLY199

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE GSH B 401

Chain	Residue
A	LYS62
A	ARG202
B	SER16
B	PRO17
B	TYR18
B	LEU44
B	MET48
B	ASN53
B	GLY182
B	LEU183
B	PHE198
B	GLY199
B	SER200
B	ASP201
B	HOH560
B	HOH669

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GSH C 801

Chain	Residue
C	SER16
C	PRO17
C	TYR18
C	GLY182
C	LEU183
C	SER200
C	ASP201
C	HOH765
D	LYS62
D	ARG202

---

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GSH D 901

Chain	Residue
C	LYS62
C	ARG202
D	SER16
D	PRO17
D	TYR18
D	MET48
D	PHE181
D	GLY182
D	LEU183
D	PHE198
D	GLY199
D	SER200
D	ASP201
D	HOH763

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14717589","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9DCM2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	28
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9DCM2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9DCM2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---