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1R4W

Crystal structure of Mitochondrial class kappa glutathione transferase

Functional Information from GO Data
ChainGOidnamespacecontents
A0004364molecular_functionglutathione transferase activity
A0004602molecular_functionglutathione peroxidase activity
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005777cellular_componentperoxisome
A0006749biological_processglutathione metabolic process
A0016491molecular_functionoxidoreductase activity
A0016740molecular_functiontransferase activity
A0030855biological_processepithelial cell differentiation
A0043231cellular_componentintracellular membrane-bounded organelle
A0098869biological_processcellular oxidant detoxification
B0004364molecular_functionglutathione transferase activity
B0004602molecular_functionglutathione peroxidase activity
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005777cellular_componentperoxisome
B0006749biological_processglutathione metabolic process
B0016491molecular_functionoxidoreductase activity
B0016740molecular_functiontransferase activity
B0030855biological_processepithelial cell differentiation
B0043231cellular_componentintracellular membrane-bounded organelle
B0098869biological_processcellular oxidant detoxification
C0004364molecular_functionglutathione transferase activity
C0004602molecular_functionglutathione peroxidase activity
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005759cellular_componentmitochondrial matrix
C0005777cellular_componentperoxisome
C0006749biological_processglutathione metabolic process
C0016491molecular_functionoxidoreductase activity
C0016740molecular_functiontransferase activity
C0030855biological_processepithelial cell differentiation
C0043231cellular_componentintracellular membrane-bounded organelle
C0098869biological_processcellular oxidant detoxification
D0004364molecular_functionglutathione transferase activity
D0004602molecular_functionglutathione peroxidase activity
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005759cellular_componentmitochondrial matrix
D0005777cellular_componentperoxisome
D0006749biological_processglutathione metabolic process
D0016491molecular_functionoxidoreductase activity
D0016740molecular_functiontransferase activity
D0030855biological_processepithelial cell differentiation
D0043231cellular_componentintracellular membrane-bounded organelle
D0098869biological_processcellular oxidant detoxification
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE GSH A 301
ChainResidue
ASER16
ASER200
AASP201
BLYS62
BARG202
APRO17
ATYR18
AASN53
APHE181
AGLY182
ALEU183
APHE198
AGLY199

site_idAC2
Number of Residues16
DetailsBINDING SITE FOR RESIDUE GSH B 401
ChainResidue
ALYS62
AARG202
BSER16
BPRO17
BTYR18
BLEU44
BMET48
BASN53
BGLY182
BLEU183
BPHE198
BGLY199
BSER200
BASP201
BHOH560
BHOH669

site_idAC3
Number of Residues10
DetailsBINDING SITE FOR RESIDUE GSH C 801
ChainResidue
CSER16
CPRO17
CTYR18
CGLY182
CLEU183
CSER200
CASP201
CHOH765
DLYS62
DARG202

site_idAC4
Number of Residues14
DetailsBINDING SITE FOR RESIDUE GSH D 901
ChainResidue
CLYS62
CARG202
DSER16
DPRO17
DTYR18
DMET48
DPHE181
DGLY182
DLEU183
DPHE198
DGLY199
DSER200
DASP201
DHOH763

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:14717589
ChainResidueDetails
APRO17
CGLN54
CPRO184
CASP201
DPRO17
DGLN54
DPRO184
DASP201
AGLN54
APRO184
AASP201
BPRO17
BGLN54
BPRO184
BASP201
CPRO17

site_idSWS_FT_FI2
Number of Residues16
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9DCM2
ChainResidueDetails
ALEU37
CASP50
CALA145
CTHR194
DLEU37
DASP50
DALA145
DTHR194
AASP50
AALA145
ATHR194
BLEU37
BASP50
BALA145
BTHR194
CLEU37

site_idSWS_FT_FI3
Number of Residues28
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9DCM2
ChainResidueDetails
AGLU69
BLYS94
BVAL117
BILE159
BLEU168
BTYR178
CGLU69
CGLN75
CLYS94
CVAL117
CILE159
AGLN75
CLEU168
CTYR178
DGLU69
DGLN75
DLYS94
DVAL117
DILE159
DLEU168
DTYR178
ALYS94
AVAL117
AILE159
ALEU168
ATYR178
BGLU69
BGLN75

site_idSWS_FT_FI4
Number of Residues8
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9DCM2
ChainResidueDetails
AASP86
ASER166
BASP86
BSER166
CASP86
CSER166
DASP86
DSER166

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PDB entries from 2024-10-30

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