1R3T
Uroporphyrinogen Decarboxylase single mutant D86G in complex with coproporphyrinogen-III
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004853 | molecular_function | uroporphyrinogen decarboxylase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006778 | biological_process | porphyrin-containing compound metabolic process |
| A | 0006779 | biological_process | porphyrin-containing compound biosynthetic process |
| A | 0006782 | biological_process | protoporphyrinogen IX biosynthetic process |
| A | 0006783 | biological_process | heme biosynthetic process |
| A | 0006784 | biological_process | heme A biosynthetic process |
| A | 0006785 | biological_process | heme B biosynthetic process |
| A | 0006787 | biological_process | porphyrin-containing compound catabolic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0042168 | biological_process | heme metabolic process |
| A | 0048034 | biological_process | heme O biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE CP3 A 867 |
| Chain | Residue |
| A | ARG37 |
| A | PHE84 |
| A | SER85 |
| A | ILE87 |
| A | PHE154 |
| A | TYR164 |
| A | PHE217 |
| A | SER219 |
| A | HIS339 |
| A | HOH1327 |
| A | HOH1333 |
| A | GLN38 |
| A | HOH1334 |
| A | HOH1337 |
| A | HOH1338 |
| A | HOH1358 |
| A | HOH1362 |
| A | ALA39 |
| A | GLY40 |
| A | ARG41 |
| A | PHE46 |
| A | PHE55 |
| A | ILE82 |
| A | ILE83 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14633982, ECO:0007744|PDB:1R3W, ECO:0007744|PDB:1R3Y |
| Chain | Residue | Details |
| A | ARG37 | |
| A | GLY86 | |
| A | HIS339 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14633982, ECO:0007744|PDB:1R3T, ECO:0007744|PDB:1R3W, ECO:0007744|PDB:1R3Y |
| Chain | Residue | Details |
| A | ALA39 | |
| A | ARG41 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14633982, ECO:0007744|PDB:1R3Q, ECO:0007744|PDB:1R3S |
| Chain | Residue | Details |
| A | ARG50 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14633982, ECO:0007744|PDB:1R3Y |
| Chain | Residue | Details |
| A | TYR164 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14633982, ECO:0007744|PDB:1R3T, ECO:0007744|PDB:1R3W |
| Chain | Residue | Details |
| A | SER219 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | SITE: Transition state stabilizer => ECO:0000269|PubMed:14633982 |
| Chain | Residue | Details |
| A | GLY86 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | MET1 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1uro |
| Chain | Residue | Details |
| A | TYR164 | |
| A | GLY86 |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 914 |
| Chain | Residue | Details |
| A | ARG37 | proton shuttle (general acid/base) |
| A | ARG41 | electrostatic stabiliser |
| A | ARG50 | proton shuttle (general acid/base) |
| A | GLY86 | enhance reactivity, modifies pKa, transition state stabiliser |
| A | TYR164 | electrostatic stabiliser |
