1R31
HMG-CoA reductase from Pseudomonas mevalonii complexed with HMG-CoA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| A | 0015936 | biological_process | coenzyme A metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0140643 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADH) activity |
| B | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| B | 0015936 | biological_process | coenzyme A metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0140643 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADH) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1000 |
| Chain | Residue |
| A | ALA184 |
| A | MET185 |
| A | GLY186 |
| A | ALA187 |
| A | ASN188 |
| A | THR189 |
| A | HOH1037 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1001 |
| Chain | Residue |
| B | MET685 |
| B | GLY686 |
| B | ALA687 |
| B | ASN688 |
| B | HOH21 |
| B | ALA684 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE COA A 1002 |
| Chain | Residue |
| A | ARG11 |
| A | ASN67 |
| A | GLU83 |
| A | PRO84 |
| A | SER85 |
| A | ALA88 |
| A | TYR92 |
| A | LYS95 |
| A | GLN364 |
| A | GLY367 |
| A | ALA368 |
| A | ARG370 |
| A | ALA371 |
| A | MEV1003 |
| A | HOH1048 |
| A | HOH1055 |
| A | HOH1057 |
| A | HOH1121 |
| A | HOH1130 |
| B | GLU552 |
| B | ASN553 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE MEV A 1003 |
| Chain | Residue |
| A | GLU83 |
| A | ARG261 |
| A | THR264 |
| A | LYS267 |
| A | ASN271 |
| A | ALA368 |
| A | LEU372 |
| A | ILE377 |
| A | COA1002 |
| A | HOH1014 |
| A | HOH1188 |
| B | HOH17 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE MEV B 1004 |
| Chain | Residue |
| B | HOH93 |
| B | HOH333 |
| B | GLU583 |
| B | ARG761 |
| B | THR764 |
| B | LYS767 |
| B | ASN771 |
| B | ALA868 |
| B | LEU872 |
Functional Information from PROSITE/UniProt
| site_id | PS00066 |
| Number of Residues | 15 |
| Details | HMG_COA_REDUCTASE_1 Hydroxymethylglutaryl-coenzyme A reductases signature 1. HlIVdVRDaMGaNtV |
| Chain | Residue | Details |
| A | HIS176-VAL190 |
| site_id | PS00318 |
| Number of Residues | 8 |
| Details | HMG_COA_REDUCTASE_2 Hydroxymethylglutaryl-coenzyme A reductases signature 2. VGlVGGAT |
| Chain | Residue | Details |
| A | VAL325-THR332 |
| site_id | PS01192 |
| Number of Residues | 14 |
| Details | HMG_COA_REDUCTASE_3 Hydroxymethylglutaryl-coenzyme A reductases signature 3. ALaTegIqRGHMaL |
| Chain | Residue | Details |
| A | ALA371-LEU384 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Charge relay system"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dqa |
| Chain | Residue | Details |
| A | GLU83 | |
| B | ARG721 | |
| B | ASP783 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1dqa |
| Chain | Residue | Details |
| A | ARG221 | |
| A | ASP283 | |
| B | GLU583 |
