1R1K
Crystal structure of the ligand-binding domains of the heterodimer EcR/USP bound to ponasterone A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003707 | molecular_function | nuclear steroid receptor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0030518 | biological_process | nuclear receptor-mediated steroid hormone signaling pathway |
| D | 0003677 | molecular_function | DNA binding |
| D | 0004879 | molecular_function | nuclear receptor activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0035076 | biological_process | ecdysone receptor signaling pathway |
| D | 0035100 | molecular_function | ecdysone binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE P1A D 3000 |
| Chain | Residue |
| D | GLU309 |
| D | LEU396 |
| D | PHE397 |
| D | ALA398 |
| D | TYR408 |
| D | MET413 |
| D | VAL416 |
| D | LEU420 |
| D | ASN504 |
| D | GLN310 |
| D | ILE339 |
| D | MET342 |
| D | THR343 |
| D | THR346 |
| D | ARG383 |
| D | VAL384 |
| D | ARG387 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE EPH A 4000 |
| Chain | Residue |
| A | LEU230 |
| A | VAL238 |
| A | PRO239 |
| A | PHE242 |
| A | LEU249 |
| A | ASN287 |
| A | LEU290 |
| A | MET323 |
| A | LEU331 |
| A | GLN338 |
| A | ALA339 |
| A | SER431 |
| A | HIS434 |
| A | PHE438 |
| A | LEU440 |
