1R1K

Crystal structure of the ligand-binding domains of the heterodimer EcR/USP bound to ponasterone A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003707	molecular_function	nuclear steroid receptor activity
A	0004879	molecular_function	nuclear receptor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008270	molecular_function	zinc ion binding
A	0030522	biological_process	intracellular receptor signaling pathway
A	0043401	biological_process	steroid hormone receptor signaling pathway
D	0003677	molecular_function	DNA binding
D	0004879	molecular_function	nuclear receptor activity
D	0005634	cellular_component	nucleus
D	0006355	biological_process	regulation of DNA-templated transcription
D	0035076	biological_process	ecdysone receptor signaling pathway
D	0035100	molecular_function	ecdysone binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE P1A D 3000

Chain	Residue
D	GLU309
D	LEU396
D	PHE397
D	ALA398
D	TYR408
D	MET413
D	VAL416
D	LEU420
D	ASN504
D	GLN310
D	ILE339
D	MET342
D	THR343
D	THR346
D	ARG383
D	VAL384
D	ARG387

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site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE EPH A 4000

Chain	Residue
A	LEU230
A	VAL238
A	PRO239
A	PHE242
A	LEU249
A	ASN287
A	LEU290
A	MET323
A	LEU331
A	GLN338
A	ALA339
A	SER431
A	HIS434
A	PHE438
A	LEU440

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