1R0R

1.1 Angstrom Resolution Structure of the Complex Between the Protein Inhibitor, OMTKY3, and the Serine Protease, Subtilisin Carlsberg

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004252	molecular_function	serine-type endopeptidase activity
E	0006508	biological_process	proteolysis
E	0008236	molecular_function	serine-type peptidase activity
I	0004867	molecular_function	serine-type endopeptidase inhibitor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA E 301

Chain	Residue
E	ALA37
E	HIS39
E	LEU42
E	HOH4096
E	HOH4097
E	HOH4126
E	HOH4333

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 302

Chain	Residue
E	LEU75
E	ASN77
E	THR79
E	VAL81
E	GLN2
E	ASP41

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 303

Chain	Residue
E	GLY193
E	ALA194
E	LEU196
E	SER260
E	HOH4174
E	HOH4286

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA E 305

Chain	Residue
E	ALA169
E	TYR171
E	VAL174
E	HOH4021
E	HOH4084

---

Functional Information from PROSITE/UniProt

site_id	PS00136
Number of Residues	12
Details	SUBTILASE_ASP Serine proteases, subtilase family, aspartic acid active site. VAVLDTGIqasH

Chain	Residue	Details
E	VAL28-HIS39

---

site_id	PS00137
Number of Residues	11
Details	SUBTILASE_HIS Serine proteases, subtilase family, histidine active site. HGThVAGtVAA

Chain	Residue	Details
E	HIS64-ALA74

---

site_id	PS00138
Number of Residues	11
Details	SUBTILASE_SER Serine proteases, subtilase family, serine active site. GTSmAsPhVAG

Chain	Residue	Details
E	GLY219-GLY229

---

site_id	PS00282
Number of Residues	23
Details	KAZAL_1 Kazal serine protease inhibitors family signature. CtleyRplCgSdnktYgnkCnf.C

Chain	Residue	Details
I	CYS16-CYS38

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	268
Details	Domain: {"description":"Peptidase S8","evidences":[{"source":"PROSITE-ProRule","id":"PRU01240","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU01240","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"8512925","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Reactive bond 3 for chymotrypsin, elastase, proteases A and B, and subtilisin"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine"}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1sca

Chain	Residue	Details
E	SER221
E	HIS64
E	ASP32

---