1QZU

crystal structure of human phosphopantothenoylcysteine decarboxylase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0010181	molecular_function	FMN binding
A	0015937	biological_process	coenzyme A biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016831	molecular_function	carboxy-lyase activity
A	0042802	molecular_function	identical protein binding
A	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
B	0003824	molecular_function	catalytic activity
B	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0010181	molecular_function	FMN binding
B	0015937	biological_process	coenzyme A biosynthetic process
B	0016829	molecular_function	lyase activity
B	0016831	molecular_function	carboxy-lyase activity
B	0042802	molecular_function	identical protein binding
B	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
C	0003824	molecular_function	catalytic activity
C	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0010181	molecular_function	FMN binding
C	0015937	biological_process	coenzyme A biosynthetic process
C	0016829	molecular_function	lyase activity
C	0016831	molecular_function	carboxy-lyase activity
C	0042802	molecular_function	identical protein binding
C	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex
D	0003824	molecular_function	catalytic activity
D	0004633	molecular_function	phosphopantothenoylcysteine decarboxylase activity
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0010181	molecular_function	FMN binding
D	0015937	biological_process	coenzyme A biosynthetic process
D	0016829	molecular_function	lyase activity
D	0016831	molecular_function	carboxy-lyase activity
D	0042802	molecular_function	identical protein binding
D	0071513	cellular_component	phosphopantothenoylcysteine decarboxylase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE FMN A 801

Chain	Residue
A	THR25
A	ASP104
A	ALA105
A	ASN106
A	THR107
A	CYS116
A	ALA138
A	MET139
A	MET143
A	GLY26
A	SER27
A	VAL28
A	THR53
A	PHE59
A	GLU75
A	TRP76
A	TRP79

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE FMN B 802

Chain	Residue
B	THR25
B	GLY26
B	SER27
B	VAL28
B	THR53
B	GLU75
B	TRP76
B	TRP79
B	ASP104
B	ALA105
B	ASN106
B	THR107
B	CYS116
B	ALA138
B	MET139
B	MET143

---

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE FMN C 803

Chain	Residue
C	GLY26
C	SER27
C	VAL28
C	THR53
C	GLU75
C	TRP76
C	TRP79
C	HIS88
C	ASP104
C	ALA105
C	ASN106
C	THR107
C	CYS116
C	ASP117
C	ALA138
C	MET139
C	MET143

---

site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE FMN D 804

Chain	Residue
D	THR25
D	GLY26
D	SER27
D	VAL28
D	THR53
D	GLU75
D	TRP76
D	TRP79
D	ASP104
D	ALA105
D	ASN106
D	THR107
D	CYS116
D	ALA138
D	MET139
D	MET143

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor => ECO:0000305|PubMed:15581364

Chain	Residue	Details
A	CYS173
B	CYS173
C	CYS173
D	CYS173

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:14501115

Chain	Residue	Details
A	PHE59
A	ASP104
B	PHE59
B	ASP104
C	PHE59
C	ASP104
D	PHE59
D	ASP104

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ASN140
B	ASN140
C	ASN140
D	ASN140

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