Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005737 | cellular_component | cytoplasm |
A | 0006569 | biological_process | tryptophan catabolic process |
A | 0009435 | biological_process | NAD biosynthetic process |
A | 0016787 | molecular_function | hydrolase activity |
A | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
A | 0019805 | biological_process | quinolinate biosynthetic process |
A | 0030170 | molecular_function | pyridoxal phosphate binding |
A | 0030429 | molecular_function | kynureninase activity |
A | 0034354 | biological_process | 'de novo' NAD biosynthetic process from tryptophan |
A | 0043420 | biological_process | anthranilate metabolic process |
A | 0061981 | molecular_function | 3-hydroxykynureninase activity |
A | 0097053 | biological_process | L-kynurenine catabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL A 601 |
Chain | Residue |
A | HIS204 |
A | ARG375 |
A | HOH1353 |
site_id | AC2 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE PLP A 1227 |
Chain | Residue |
A | THR172 |
A | ASP201 |
A | ALA203 |
A | HIS204 |
A | CYS224 |
A | TYR226 |
A | LYS227 |
A | TRP256 |
A | GLY281 |
A | THR282 |
A | HOH1256 |
A | THR96 |
A | THR97 |
A | SER98 |
A | PHE129 |
A | THR131 |
A | ASP132 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE P3G A 701 |
Chain | Residue |
A | TRP256 |
A | HIS259 |
A | ARG261 |
A | MET265 |
A | ARG369 |
A | HOH1636 |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | THR97 | |
A | SER98 | |
A | THR172 | |
A | ASP201 | |
A | HIS204 | |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | BINDING: |
Chain | Residue | Details |
A | PHE129 | |
Chain | Residue | Details |
A | TYR226 | |
A | TRP256 | |
A | THR282 | |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: N6-(pyridoxal phosphate)lysine |
Chain | Residue | Details |
A | LYS227 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | a catalytic site defined by CSA, PubMed 14756555 |
Chain | Residue | Details |
A | ASP201 | |
A | PHE129 | |
A | LYS227 | |
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 742 |
Chain | Residue | Details |
A | PHE129 | electrostatic stabiliser |
A | ASP201 | electrostatic stabiliser |
A | TYR226 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
A | LYS227 | electron pair acceptor, nucleofuge, nucleophile, proton acceptor, proton donor |
A | ARG375 | electrostatic stabiliser |