Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1QXO

Crystal structure of Chorismate synthase complexed with oxidized FMN and EPSP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004107	molecular_function	chorismate synthase activity
A	0005829	cellular_component	cytosol
A	0008652	biological_process	amino acid biosynthetic process
A	0009073	biological_process	aromatic amino acid family biosynthetic process
A	0009423	biological_process	chorismate biosynthetic process
A	0010181	molecular_function	FMN binding
A	0016829	molecular_function	lyase activity
B	0004107	molecular_function	chorismate synthase activity
B	0005829	cellular_component	cytosol
B	0008652	biological_process	amino acid biosynthetic process
B	0009073	biological_process	aromatic amino acid family biosynthetic process
B	0009423	biological_process	chorismate biosynthetic process
B	0010181	molecular_function	FMN binding
B	0016829	molecular_function	lyase activity
C	0004107	molecular_function	chorismate synthase activity
C	0005829	cellular_component	cytosol
C	0008652	biological_process	amino acid biosynthetic process
C	0009073	biological_process	aromatic amino acid family biosynthetic process
C	0009423	biological_process	chorismate biosynthetic process
C	0010181	molecular_function	FMN binding
C	0016829	molecular_function	lyase activity
D	0004107	molecular_function	chorismate synthase activity
D	0005829	cellular_component	cytosol
D	0008652	biological_process	amino acid biosynthetic process
D	0009073	biological_process	aromatic amino acid family biosynthetic process
D	0009423	biological_process	chorismate biosynthetic process
D	0010181	molecular_function	FMN binding
D	0016829	molecular_function	lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NCO C 2001

Chain	Residue
C	ASN387
C	TYR388
C	HOH5429

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NCO A 2002

Chain	Residue
A	ASP170
A	GLU173
C	ASP210
C	HOH5406

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NCO B 2003

Chain	Residue
B	ALA151
B	ASP154

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NCO A 2004

Chain	Residue
A	ARG120
A	ASP122
A	HOH5434
C	GLU372

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE NCO C 2005

Chain	Residue
C	GLU168
C	GLU263
C	FMN4005
C	HOH5099
C	HOH5262
C	HOH5455
D	TYR266
D	FMN4006

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE NCO D 2006

Chain	Residue
C	FMN4005
C	HOH5231
D	GLU168
D	GLU263
D	FMN4006
D	HOH5215
D	HOH5351
D	HOH5385

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NCO A 2007

Chain	Residue
A	ASN387
A	HOH5407
A	HOH5436

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NCO B 2008

Chain	Residue
B	ASN387
B	TYR388
B	HOH5476

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NCO D 2009

Chain	Residue
D	ASN387
D	TYR388

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 3001

Chain	Residue
A	TYR284
A	ARG286
A	ASN300
A	THR385
A	HOH5197
A	HOH5265
B	ILE117

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO B 3002

Chain	Residue
A	ILE117
B	VAL227
B	TYR284
B	ARG286
B	ASN300
B	THR385
B	HOH5068
B	HOH5225

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO C 3003

Chain	Residue
C	VAL227
C	TYR284
C	ARG286
C	ASN300
C	THR385
C	HOH5019
C	HOH5208
D	ILE117

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO D 3004

Chain	Residue
C	ILE117
D	TYR284
D	ARG286
D	ASN300
D	HOH5030
D	HOH5220

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 3005

Chain	Residue
A	HOH5073
A	HOH5085

site_id	BC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO A 3006

Chain	Residue
A	GLY20
A	ILE21
A	PRO22
A	SER368
A	ASP369
A	HOH5156
A	HOH5214
A	HOH5230
D	ARG237

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO D 3007

Chain	Residue
D	LEU4
D	HOH5131
D	HOH5219

site_id	BC8
Number of Residues	25
Details	BINDING SITE FOR RESIDUE FMN A 4001

Chain	Residue
A	HOH5208
A	HOH5277
A	HOH5330
A	HOH5454
B	GLY296
B	HOH5003
A	ARG45
A	GLY109
A	HIS110
A	SER131
A	ALA133
A	ASN251
A	ALA252
A	MSE310
A	LYS311
A	ILE313
A	PRO314
A	THR315
A	ALA342
A	EPS5001
A	HOH5034
A	HOH5035
A	HOH5037
A	HOH5072
A	HOH5192

site_id	BC9
Number of Residues	23
Details	BINDING SITE FOR RESIDUE FMN B 4002

Chain	Residue
A	GLU295
A	GLY296
A	HOH5031
B	GLY109
B	HIS110
B	SER131
B	ALA133
B	ASN251
B	ALA252
B	MSE310
B	LYS311
B	ILE313
B	PRO314
B	THR315
B	SER338
B	ASP339
B	ALA342
B	EPS5002
B	HOH5006
B	HOH5008
B	HOH5041
B	HOH5232
B	HOH5530

site_id	CC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE FMN C 4003

Chain	Residue
C	GLY109
C	HIS110
C	SER131
C	ALA133
C	ASN251
C	ALA252
C	MSE310
C	LYS311
C	ILE313
C	PRO314
C	THR315
C	SER338
C	ALA342
C	EPS5003
C	HOH5017
C	HOH5028
C	HOH5034
C	HOH5095
C	HOH5472
D	GLY296
D	HOH5080

site_id	CC2
Number of Residues	22
Details	BINDING SITE FOR RESIDUE FMN D 4004

Chain	Residue
C	GLU295
C	GLY296
D	GLY109
D	HIS110
D	SER131
D	ALA133
D	ASN251
D	ALA252
D	MSE310
D	LYS311
D	ILE313
D	PRO314
D	THR315
D	SER338
D	ALA342
D	EPS5004
D	HOH5011
D	HOH5043
D	HOH5049
D	HOH5063
D	HOH5178
D	HOH5483

site_id	CC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE FMN C 4005

Chain	Residue
A	HOH5428
B	LYS167
B	HOH5415
C	PHE262
C	GLU263
C	TYR266
C	NCO2005
C	HOH5084
C	HOH5099
C	HOH5231
C	HOH5262
C	HOH5376
D	NCO2006
D	FMN4006
D	HOH5187
D	HOH5215
D	HOH5425

site_id	CC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE FMN D 4006

Chain	Residue
B	ARG196
C	NCO2005
C	FMN4005
C	HOH5084
C	HOH5099
D	PHE262
D	GLU263
D	TYR266
D	NCO2006
D	HOH5135
D	HOH5217
D	HOH5330
D	HOH5374
D	HOH5379
D	HOH5450
D	HOH5464

site_id	CC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE EPS A 5001

Chain	Residue
A	HIS10
A	ARG39
A	ARG45
A	ARG48
A	MSE49
A	HIS110
A	SER132
A	ALA133
A	ARG134
A	FMN4001
A	HOH5058
A	HOH5153
A	HOH5277

site_id	CC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE EPS B 5002

Chain	Residue
B	HIS10
B	ARG39
B	ARG45
B	ARG48
B	MSE49
B	HIS110
B	SER132
B	ALA133
B	ARG134
B	ARG337
B	FMN4002
B	HOH5075
B	HOH5108
B	HOH5116
B	HOH5121
B	HOH5258

site_id	CC7
Number of Residues	16
Details	BINDING SITE FOR RESIDUE EPS C 5003

Chain	Residue
C	HIS10
C	ARG39
C	ARG45
C	ARG48
C	MSE49
C	HIS110
C	SER132
C	ALA133
C	ARG134
C	ARG337
C	FMN4003
C	HOH5076
C	HOH5131
C	HOH5160
C	HOH5184
C	HOH5186

site_id	CC8
Number of Residues	16
Details	BINDING SITE FOR RESIDUE EPS D 5004

Chain	Residue
D	HIS10
D	ARG39
D	ARG45
D	ARG48
D	MSE49
D	HIS110
D	SER132
D	ALA133
D	ARG134
D	ARG337
D	FMN4004
D	HOH5093
D	HOH5110
D	HOH5119
D	HOH5208
D	HOH5256

Functional Information from PROSITE/UniProt

site_id	PS00787
Number of Residues	16
Details	CHORISMATE_SYNTHASE_1 Chorismate synthase signature 1. GESHGprLTaIIEGiP

Chain	Residue	Details
A	GLY7-PRO22

site_id	PS00788
Number of Residues	17
Details	CHORISMATE_SYNTHASE_2 Chorismate synthase signature 2. ErsSAReTtmrVavGAV

Chain	Residue	Details
A	GLU129-VAL145

site_id	PS00789
Number of Residues	17
Details	CHORISMATE_SYNTHASE_3 Chorismate synthase signature 3. RSDPTalpaAgMVmEAV

Chain	Residue	Details
A	ARG337-VAL353

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00300","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00300","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14656434","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)