1QWT

Auto-inhibitory interferon regulation factor-3 (IRF3) transactivation domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 A 601

Chain	Residue
A	LYS193
A	SER266
A	GLY269
A	HIS288
A	HOH626
A	HOH833
A	HOH856

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 A 602

Chain	Residue
A	TRP202
A	PHE204
A	CYS222
A	ARG276
A	HOH615
A	HOH644
A	HOH669
A	GLU200
A	GLU201

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 A 603

Chain	Residue
A	GLU224
A	PRO239
A	TRP275
A	HOH764
A	HOH823
A	HOH855

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 B 604

Chain	Residue
B	LYS193
B	SER266
B	GLY269
B	HIS288
B	HOH762
B	HOH856

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 B 605

Chain	Residue
B	GLU200
B	GLU201
B	TRP202
B	PHE204
B	CYS222
B	ARG276
B	HOH613
B	HOH618
B	HOH851

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 B 606

Chain	Residue
B	GLU224
B	PRO239
B	TRP275
B	HOH646
B	HOH758
B	HOH854

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 B 607

Chain	Residue
B	ARG194
B	HIS399
B	PRO400
B	HOH761
B	HOH850

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 B 608

Chain	Residue
B	SER259
B	TYR260
B	HIS263
B	GLU350
B	HOH660
B	HOH726
B	HOH834

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	320
Details	Region: {"description":"Interaction with HERC5","evidences":[{"source":"PubMed","id":"20308324","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23746807","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P70671","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22394562","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by TBK1","evidences":[{"source":"PubMed","id":"22394562","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746807","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27302953","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36603579","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by IKKE and TBK1","evidences":[{"source":"PubMed","id":"22394562","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23478265","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27302953","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36603579","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23746807","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)","evidences":[{"source":"PubMed","id":"20308324","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---