1QVT

CRYSTAL STRUCTURE OF THE MULTIDRUG BINDING TRANSCRIPTIONAL REPRESSOR QACR BOUND TO THE DRUG PROFLAVINE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006351	biological_process	DNA-templated transcription
A	0045892	biological_process	negative regulation of DNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006351	biological_process	DNA-templated transcription
B	0045892	biological_process	negative regulation of DNA-templated transcription
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0006351	biological_process	DNA-templated transcription
D	0045892	biological_process	negative regulation of DNA-templated transcription
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0006351	biological_process	DNA-templated transcription
E	0045892	biological_process	negative regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 200

Chain	Residue
A	ASN2
A	ASP5
A	LYS6

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 201

Chain	Residue
A	LYS4
A	TYR41
A	HIS42
A	HOH328

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 203

Chain	Residue
D	THR45
D	LYS46
D	SO4209
D	THR25
D	TYR40

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 204

Chain	Residue
E	THR24
E	THR25
E	GLY26
E	GLU27
E	LYS36

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 205

Chain	Residue
B	LYS66
B	SO4210
D	ASN2
D	LYS4
D	HIS42

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 206

Chain	Residue
D	THR24
D	GLY26
D	LYS30
E	LYS108

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 207

Chain	Residue
E	LYS36
E	TYR40
E	THR45
E	LYS46

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 208

Chain	Residue
A	VAL29
A	SER35
A	LYS36
E	LYS60

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 209

Chain	Residue
D	TYR20
D	LYS46
D	GLU105
D	TYR106
D	SO4203

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 210

Chain	Residue
B	LYS66
D	ASN2
D	LEU3
D	ASN38
D	HIS42
D	SO4205

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 211

Chain	Residue
E	LYS12
E	ILE53
E	ILE56
E	GLU57

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 212

Chain	Residue
A	LYS36
A	TYR40
E	ASN2
E	ASP5
E	LYS6

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 213

Chain	Residue
A	LYS12
A	ILE53
A	ILE56
A	GLU57
A	LYS60

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 214

Chain	Residue
E	LYS4
E	TYR41
E	HIS42

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 215

Chain	Residue
B	GLN64
B	GLU90
B	TYR91
D	GLN64
D	TYR91

---

site_id	BC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 B 216

Chain	Residue
B	ASN2

---

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 217

Chain	Residue
B	THR24
B	THR25
B	LYS46

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 218

Chain	Residue
A	LEU3
A	LYS4
A	ASN38
A	HIS42
E	GLU13

---

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 219

Chain	Residue
B	ILE70
B	LYS73
D	HIS164
D	GLU165
E	TYR107

---

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 220

Chain	Residue
E	HIS128
E	LYS132
E	HOH236

---

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 221

Chain	Residue
D	GLU13
D	LYS17
D	LYS30
D	GLU33
D	HOH234

---

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 222

Chain	Residue
D	LYS173
E	ASP144
E	ALA147

---

site_id	CC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 223

Chain	Residue
D	HIS128
D	LYS132

---

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 224

Chain	Residue
A	LYS6
A	HOH333
A	HOH337

---

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 225

Chain	Residue
D	GLU90
D	TYR91
B	LYS67
D	LYS60

---

site_id	CC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 226

Chain	Residue
A	LYS132

---

site_id	CC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PRL A 311

Chain	Residue
A	GLU58
A	TRP61
A	THR89
A	TYR93
A	ILE99
A	TYR103

---

Functional Information from PROSITE/UniProt

site_id	PS01081
Number of Residues	31
Details	HTH_TETR_1 TetR-type HTH domain signature. GYnatTTgeIvklseSSkGnLYyHFkTKen.L

Chain	Residue	Details
B	GLY19-LEU49

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	76
Details	DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00335","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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