Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1QRD

QUINONE REDUCTASE/FAD/CIBACRON BLUE/DUROQUINONE COMPLEX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002931	biological_process	response to ischemia
A	0003955	molecular_function	NAD(P)H dehydrogenase (quinone) activity
A	0004784	molecular_function	superoxide dismutase activity
A	0005829	cellular_component	cytosol
A	0006743	biological_process	ubiquinone metabolic process
A	0006801	biological_process	superoxide metabolic process
A	0006979	biological_process	response to oxidative stress
A	0007584	biological_process	response to nutrient
A	0008753	molecular_function	NADPH dehydrogenase (quinone) activity
A	0009410	biological_process	response to xenobiotic stimulus
A	0009725	biological_process	response to hormone
A	0009743	biological_process	response to carbohydrate
A	0019430	biological_process	removal of superoxide radicals
A	0030425	cellular_component	dendrite
A	0032355	biological_process	response to estradiol
A	0033574	biological_process	response to testosterone
A	0042177	biological_process	negative regulation of protein catabolic process
A	0042360	biological_process	vitamin E metabolic process
A	0042373	biological_process	vitamin K metabolic process
A	0043025	cellular_component	neuronal cell body
A	0043066	biological_process	negative regulation of apoptotic process
A	0043279	biological_process	response to alkaloid
A	0043525	biological_process	positive regulation of neuron apoptotic process
A	0045471	biological_process	response to ethanol
A	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
A	0051602	biological_process	response to electrical stimulus
A	0070301	biological_process	cellular response to hydrogen peroxide
A	0071248	biological_process	cellular response to metal ion
A	0110076	biological_process	negative regulation of ferroptosis
A	1902690	biological_process	positive regulation of NAD metabolic process
A	1904772	biological_process	response to tetrachloromethane
A	1904844	biological_process	response to L-glutamine
A	1904880	biological_process	response to hydrogen sulfide
A	1905395	biological_process	response to flavonoid
B	0002931	biological_process	response to ischemia
B	0003955	molecular_function	NAD(P)H dehydrogenase (quinone) activity
B	0004784	molecular_function	superoxide dismutase activity
B	0005829	cellular_component	cytosol
B	0006743	biological_process	ubiquinone metabolic process
B	0006801	biological_process	superoxide metabolic process
B	0006979	biological_process	response to oxidative stress
B	0007584	biological_process	response to nutrient
B	0008753	molecular_function	NADPH dehydrogenase (quinone) activity
B	0009410	biological_process	response to xenobiotic stimulus
B	0009725	biological_process	response to hormone
B	0009743	biological_process	response to carbohydrate
B	0019430	biological_process	removal of superoxide radicals
B	0030425	cellular_component	dendrite
B	0032355	biological_process	response to estradiol
B	0033574	biological_process	response to testosterone
B	0042177	biological_process	negative regulation of protein catabolic process
B	0042360	biological_process	vitamin E metabolic process
B	0042373	biological_process	vitamin K metabolic process
B	0043025	cellular_component	neuronal cell body
B	0043066	biological_process	negative regulation of apoptotic process
B	0043279	biological_process	response to alkaloid
B	0043525	biological_process	positive regulation of neuron apoptotic process
B	0045471	biological_process	response to ethanol
B	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
B	0051602	biological_process	response to electrical stimulus
B	0070301	biological_process	cellular response to hydrogen peroxide
B	0071248	biological_process	cellular response to metal ion
B	0110076	biological_process	negative regulation of ferroptosis
B	1902690	biological_process	positive regulation of NAD metabolic process
B	1904772	biological_process	response to tetrachloromethane
B	1904844	biological_process	response to L-glutamine
B	1904880	biological_process	response to hydrogen sulfide
B	1905395	biological_process	response to flavonoid

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE FAD A 274

Chain	Residue
A	HIS11
A	TYR104
A	TRP105
A	PHE106
A	THR147
A	THR148
A	GLY149
A	GLY150
A	TYR155
A	ILE192
A	ARG200
A	THR15
A	CBD275
A	DQN276
A	HOH294
A	SER16
A	PHE17
A	ASN18
A	ALA20
A	GLN66
A	PRO102
A	LEU103

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE CBD A 275

Chain	Residue
A	PRO68
A	TYR128
A	ALA129
A	LYS134
A	GLY149
A	GLY193
A	HIS194
A	LEU230
A	ASN231
A	PHE232
A	PHE236
A	FAD274
A	DQN276

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE DQN A 276

Chain	Residue
A	TRP105
A	PHE106
A	TYR126
A	TYR128
A	TYR155
A	HIS161
A	GLY174
A	PHE178
A	FAD274
A	CBD275

site_id	AC4
Number of Residues	22
Details	BINDING SITE FOR RESIDUE FAD B 274

Chain	Residue
B	HIS11
B	THR15
B	SER16
B	PHE17
B	ASN18
B	ALA20
B	ASN64
B	GLN66
B	PRO102
B	LEU103
B	TYR104
B	TRP105
B	PHE106
B	THR147
B	THR148
B	GLY149
B	GLY150
B	TYR155
B	ARG200
B	CBD275
B	DQN276
B	HOH293

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE CBD B 275

Chain	Residue
B	PRO68
B	TYR128
B	ALA129
B	GLY149
B	HIS194
B	LEU230
B	ASN231
B	PHE232
B	PHE236
B	FAD274
B	DQN276

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE DQN B 276

Chain	Residue
B	TRP105
B	PHE106
B	TYR126
B	TYR128
B	TYR155
B	HIS161
B	GLY174
B	PHE178
B	FAD274
B	CBD275

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	98
Details	Region: {"description":"Important for apoenzyme conformational stability","evidences":[{"source":"UniProtKB","id":"P15559","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	22
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7568029","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"3143406","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P15559","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"UniProtKB","id":"P15559","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1d4a

Chain	Residue	Details
A	TYR155
A	HIS161
A	GLY149

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1d4a

Chain	Residue	Details
B	TYR155
B	HIS161
B	GLY149

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)