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1QRD

QUINONE REDUCTASE/FAD/CIBACRON BLUE/DUROQUINONE COMPLEX

Functional Information from GO Data
ChainGOidnamespacecontents
A0000209biological_processprotein polyubiquitination
A0002931biological_processresponse to ischemia
A0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
A0004784molecular_functionsuperoxide dismutase activity
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006116biological_processNADH oxidation
A0006743biological_processubiquinone metabolic process
A0006801biological_processsuperoxide metabolic process
A0006979biological_processresponse to oxidative stress
A0007584biological_processresponse to nutrient
A0008753molecular_functionNADPH dehydrogenase (quinone) activity
A0009410biological_processresponse to xenobiotic stimulus
A0009725biological_processresponse to hormone
A0009743biological_processresponse to carbohydrate
A0010033biological_processresponse to organic substance
A0014070biological_processresponse to organic cyclic compound
A0014075biological_processresponse to amine
A0016491molecular_functionoxidoreductase activity
A0019430biological_processremoval of superoxide radicals
A0030163biological_processprotein catabolic process
A0030425cellular_componentdendrite
A0032355biological_processresponse to estradiol
A0032496biological_processresponse to lipopolysaccharide
A0033574biological_processresponse to testosterone
A0034599biological_processcellular response to oxidative stress
A0042177biological_processnegative regulation of protein catabolic process
A0042360biological_processvitamin E metabolic process
A0042373biological_processvitamin K metabolic process
A0042802molecular_functionidentical protein binding
A0043025cellular_componentneuronal cell body
A0043066biological_processnegative regulation of apoptotic process
A0043279biological_processresponse to alkaloid
A0043525biological_processpositive regulation of neuron apoptotic process
A0045087biological_processinnate immune response
A0045454biological_processcell redox homeostasis
A0045471biological_processresponse to ethanol
A0050136molecular_functionNADH:ubiquinone reductase (non-electrogenic) activity
A0051602biological_processresponse to electrical stimulus
A0070301biological_processcellular response to hydrogen peroxide
A0070995biological_processNADPH oxidation
A0071248biological_processcellular response to metal ion
A0110076biological_processnegative regulation of ferroptosis
A1901698biological_processresponse to nitrogen compound
A1904772biological_processresponse to tetrachloromethane
A1904844biological_processresponse to L-glutamine
A1904880biological_processresponse to hydrogen sulfide
A1905395biological_processresponse to flavonoid
B0000209biological_processprotein polyubiquitination
B0002931biological_processresponse to ischemia
B0003955molecular_functionNAD(P)H dehydrogenase (quinone) activity
B0004784molecular_functionsuperoxide dismutase activity
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006116biological_processNADH oxidation
B0006743biological_processubiquinone metabolic process
B0006801biological_processsuperoxide metabolic process
B0006979biological_processresponse to oxidative stress
B0007584biological_processresponse to nutrient
B0008753molecular_functionNADPH dehydrogenase (quinone) activity
B0009410biological_processresponse to xenobiotic stimulus
B0009725biological_processresponse to hormone
B0009743biological_processresponse to carbohydrate
B0010033biological_processresponse to organic substance
B0014070biological_processresponse to organic cyclic compound
B0014075biological_processresponse to amine
B0016491molecular_functionoxidoreductase activity
B0019430biological_processremoval of superoxide radicals
B0030163biological_processprotein catabolic process
B0030425cellular_componentdendrite
B0032355biological_processresponse to estradiol
B0032496biological_processresponse to lipopolysaccharide
B0033574biological_processresponse to testosterone
B0034599biological_processcellular response to oxidative stress
B0042177biological_processnegative regulation of protein catabolic process
B0042360biological_processvitamin E metabolic process
B0042373biological_processvitamin K metabolic process
B0042802molecular_functionidentical protein binding
B0043025cellular_componentneuronal cell body
B0043066biological_processnegative regulation of apoptotic process
B0043279biological_processresponse to alkaloid
B0043525biological_processpositive regulation of neuron apoptotic process
B0045087biological_processinnate immune response
B0045454biological_processcell redox homeostasis
B0045471biological_processresponse to ethanol
B0050136molecular_functionNADH:ubiquinone reductase (non-electrogenic) activity
B0051602biological_processresponse to electrical stimulus
B0070301biological_processcellular response to hydrogen peroxide
B0070995biological_processNADPH oxidation
B0071248biological_processcellular response to metal ion
B0110076biological_processnegative regulation of ferroptosis
B1901698biological_processresponse to nitrogen compound
B1904772biological_processresponse to tetrachloromethane
B1904844biological_processresponse to L-glutamine
B1904880biological_processresponse to hydrogen sulfide
B1905395biological_processresponse to flavonoid
Functional Information from PDB Data
site_idAC1
Number of Residues22
DetailsBINDING SITE FOR RESIDUE FAD A 274
ChainResidue
AHIS11
ATYR104
ATRP105
APHE106
ATHR147
ATHR148
AGLY149
AGLY150
ATYR155
AILE192
AARG200
ATHR15
ACBD275
ADQN276
AHOH294
ASER16
APHE17
AASN18
AALA20
AGLN66
APRO102
ALEU103

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE CBD A 275
ChainResidue
APRO68
ATYR128
AALA129
ALYS134
AGLY149
AGLY193
AHIS194
ALEU230
AASN231
APHE232
APHE236
AFAD274
ADQN276

site_idAC3
Number of Residues10
DetailsBINDING SITE FOR RESIDUE DQN A 276
ChainResidue
ATRP105
APHE106
ATYR126
ATYR128
ATYR155
AHIS161
AGLY174
APHE178
AFAD274
ACBD275

site_idAC4
Number of Residues22
DetailsBINDING SITE FOR RESIDUE FAD B 274
ChainResidue
BHIS11
BTHR15
BSER16
BPHE17
BASN18
BALA20
BASN64
BGLN66
BPRO102
BLEU103
BTYR104
BTRP105
BPHE106
BTHR147
BTHR148
BGLY149
BGLY150
BTYR155
BARG200
BCBD275
BDQN276
BHOH293

site_idAC5
Number of Residues11
DetailsBINDING SITE FOR RESIDUE CBD B 275
ChainResidue
BPRO68
BTYR128
BALA129
BGLY149
BHIS194
BLEU230
BASN231
BPHE232
BPHE236
BFAD274
BDQN276

site_idAC6
Number of Residues10
DetailsBINDING SITE FOR RESIDUE DQN B 276
ChainResidue
BTRP105
BPHE106
BTYR126
BTYR128
BTYR155
BHIS161
BGLY174
BPHE178
BFAD274
BCBD275

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsBINDING: BINDING => ECO:0000269|PubMed:7568029
ChainResidueDetails
AALA12
BTYR67
BTYR104
BTHR148
BSER156
BVAL201
AASN18
ATYR67
ATYR104
ATHR148
ASER156
AVAL201
BALA12
BASN18

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
ATYR126
BTYR126

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:3143406
ChainResidueDetails
AVAL2
BVAL2

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P15559
ChainResidueDetails
APRO82
BPRO82

site_idSWS_FT_FI5
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250|UniProtKB:P15559
ChainResidueDetails
APHE251
BPHE251

Catalytic Information from CSA
site_idCSA1
Number of Residues3
DetailsAnnotated By Reference To The Literature 1d4a
ChainResidueDetails
ATYR155
AHIS161
AGLY149

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1d4a
ChainResidueDetails
BTYR155
BHIS161
BGLY149

219140

PDB entries from 2024-05-01

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